Detailed information of TA system TA136706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 2889337..2889913
• Replicon: chromosome
• Accession: NZ_CP042945
• Organism: Escherichia fergusonii strain ATCC 35471

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: -
• Locus tag: FV159_RS15030
• Protein ID: WP_024256621.1
• Coordinates: 2889337..2889624 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: A0A829G8Z0
• Locus tag: FV159_RS15035
• Protein ID: WP_000063156.1
• Coordinates: 2889611..2889913 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FV159_RS15020	2884672..2888184	-	3513	WP_000981390.1	type I restriction-modification system endonuclease	-
FV159_RS15025	2888447..2889181	+	735	WP_000208600.1	hypothetical protein	-
FV159_RS15030	2889337..2889624	+	288	WP_024256621.1	BrnT family toxin	Toxin
FV159_RS15035	2889611..2889913	+	303	WP_000063156.1	BrnA antitoxin family protein	Antitoxin
FV159_RS15040	2889947..2890903	-	957	WP_001297640.1	GTPase	-
FV159_RS15045	2890914..2891117	-	204	WP_000467859.1	YbdD/YjiX family protein	-
FV159_RS15050	2891167..2893317	-	2151	WP_001314407.1	pyruvate/proton symporter BtsT	-
FV159_RS15055	2893587..2894099	-	513	WP_001175454.1	4-hydroxyphenylacetate 3-monooxygenase reductase subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (37-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11267.72 Da
• Isoelectric Point: 6.8816

>T136706 WP_024256621.1 NZ_CP042945:2889337-2889624 [Escherichia fergusonii]
MPMEFEWDANKAKSNRVKHDIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Nucleotide

• Length: 288 bp

>T136706 NZ_CP042945:2889337-2889624 [Escherichia fergusonii]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGACATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11521.99 Da
• Isoelectric Point: 9.4646

>AT136706 WP_000063156.1 NZ_CP042945:2889611-2889913 [Escherichia fergusonii]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Nucleotide

• Length: 303 bp

>AT136706 NZ_CP042945:2889611-2889913 [Escherichia fergusonii]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A829G8Z0