Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 54666..55225 Replicon plasmid pATCC-35472_2
Accession NZ_CP042944
Organism Escherichia fergusonii strain ATCC 35471

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag FV159_RS00600 Protein ID WP_000421257.1
Coordinates 54950..55225 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag FV159_RS00595 Protein ID WP_001178089.1
Coordinates 54666..54950 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FV159_RS00550 50314..50847 - 534 WP_001372168.1 transcription termination factor NusG -
FV159_RS00560 51289..51576 - 288 WP_000074855.1 conjugal transfer protein TraA -
FV159_RS00565 51494..51757 - 264 WP_001387472.1 ash family protein -
FV159_RS00580 52730..53761 + 1032 WP_000907873.1 replication initiation protein -
FV159_RS00595 54666..54950 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
FV159_RS00600 54950..55225 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FV159_RS00605 55300..55800 - 501 WP_024230392.1 hypothetical protein -
FV159_RS00610 55856..56464 - 609 WP_096970051.1 proQ/FINO family protein -
FV159_RS00615 56640..57692 - 1053 WP_000655519.1 hypothetical protein -
FV159_RS00620 57904..58493 - 590 Protein_58 hypothetical protein -
FV159_RS00625 58493..58745 - 253 Protein_59 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..74679 74679


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T136688 WP_000421257.1 NZ_CP042944:54950-55225 [Escherichia fergusonii]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T136688 NZ_CP042944:54950-55225 [Escherichia fergusonii]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT136688 WP_001178089.1 NZ_CP042944:54666-54950 [Escherichia fergusonii]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT136688 NZ_CP042944:54666-54950 [Escherichia fergusonii]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References