Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 39906..40453 Replicon plasmid pATCC-35471_1
Accession NZ_CP042943
Organism Escherichia fergusonii strain ATCC 35471

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag FV159_RS00265 Protein ID WP_000969996.1
Coordinates 40172..40453 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag FV159_RS00260 Protein ID WP_000079928.1
Coordinates 39906..40175 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FV159_RS00210 35541..35753 + 213 WP_001299730.1 ANR family transcriptional regulator -
FV159_RS00215 35999..36460 + 462 WP_000978818.1 thermonuclease family protein -
FV159_RS00220 36506..36715 + 210 WP_021573170.1 hemolysin expression modulator Hha -
FV159_RS00225 36754..37344 + 591 WP_021573171.1 DUF2726 domain-containing protein -
FV159_RS00230 37584..37844 + 261 WP_000083819.1 replication regulatory protein RepA -
FV159_RS00240 38068..38142 + 75 WP_001375168.1 RepA leader peptide Tap -
FV159_RS00245 38135..38992 + 858 WP_000130961.1 incFII family plasmid replication initiator RepA -
FV159_RS00260 39906..40175 + 270 WP_000079928.1 hypothetical protein Antitoxin
FV159_RS00265 40172..40453 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FV159_RS00270 40578..40886 + 309 WP_001450829.1 hypothetical protein -
FV159_RS00275 40904..41494 - 591 WP_000194550.1 hypothetical protein -
FV159_RS00280 41494..41748 - 255 WP_000343103.1 hypothetical protein -
FV159_RS00285 42100..42599 + 500 WP_123001832.1 DUF4238 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..42599 42599


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T136683 WP_000969996.1 NZ_CP042943:40172-40453 [Escherichia fergusonii]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T136683 NZ_CP042943:40172-40453 [Escherichia fergusonii]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCACATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT136683 WP_000079928.1 NZ_CP042943:39906-40175 [Escherichia fergusonii]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT136683 NZ_CP056180:4771043-4771495 [Citrobacter sp. RHBSTW-01044]
ATGAGAACGCATGAAAGCCATCAGATAGACACAGCCAGTGTAAAATTGATGATCGATACCTTTACCGATGCAGTGAAAAA
AATCCCCCTGTTAGGCAAAGAACAAAATGAGACAGAGTACCGAAAAGCACTCGCTTTGGTGGAGTTTCTGGTTGATCGTG
ACGACCTGGAAAACCCGTTGTTTGAGCTGCTTTCAGCTCGGATCCGCGACTACGAAAAACATGCGCCTGAGTTCAGTGCC
CTCAACCAACAACTGGAACATACTCCTCATGGCGTTACGTTACTGCGTACGCTCATGGATCAATATGGTCTCAAAGCAGC
AGATCTTGCCAACGAACTTGGTTCAAAATCCAATGTCAGCAACATCTTGAATGGTCGCAGAGCACTGACTGTAAGTCATA
TTAAAATGCTCGCAGAACGCTTTAACCTTCCGGCAGACGCATTCATCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References