Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2089544..2090094 Replicon chromosome
Accession NZ_CP042942
Organism Escherichia fergusonii strain ATCC 35473

Toxin (Protein)


Gene name ccdB Uniprot ID F0JPU1
Locus tag FV158_RS10340 Protein ID WP_001160963.1
Coordinates 2089780..2090094 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag FV158_RS10335 Protein ID WP_000125566.1
Coordinates 2089544..2089777 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FV158_RS10310 2084616..2084903 + 288 WP_000203741.1 ferredoxin-like protein FixX -
FV158_RS10315 2084962..2086293 + 1332 WP_148047983.1 MFS transporter -
FV158_RS10320 2086401..2086931 + 531 WP_148047984.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
FV158_RS10325 2086924..2088786 + 1863 WP_148047985.1 glutathione-regulated potassium-efflux system protein KefC -
FV158_RS10330 2088979..2089458 + 480 WP_000624375.1 type 3 dihydrofolate reductase -
FV158_RS10335 2089544..2089777 + 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
FV158_RS10340 2089780..2090094 + 315 WP_001160963.1 CcdB family protein Toxin
FV158_RS10345 2090091..2090939 - 849 WP_000257189.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
FV158_RS10350 2090946..2091323 - 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
FV158_RS10355 2091326..2092147 - 822 WP_001065388.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
FV158_RS10360 2092144..2093133 - 990 WP_046076786.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
FV158_RS10365 2093133..2094419 - 1287 WP_000800490.1 peptidylprolyl isomerase SurA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11722.70 Da        Isoelectric Point: 8.0666

>T136668 WP_001160963.1 NZ_CP042942:2089780-2090094 [Escherichia fergusonii]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSHIRPPERLNPILLLVDGKEYVLMTHETATVPVNTLG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T136668 NZ_CP056168:3577993-3578211 [Enterobacter roggenkampii]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACCCTCGAACGCGT
GATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCCGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAGC
TGACCATGAATAAGTTGTATGACAAAATCCCTACTTCTGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT136668 WP_000125566.1 NZ_CP042942:2089544-2089777 [Escherichia fergusonii]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT136668 NZ_CP042942:2089544-2089777 [Escherichia fergusonii]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F0JPU1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References