Detailed information of TA system TA136665

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1871041..1871563
• Replicon: chromosome
• Accession: NZ_CP042942
• Organism: Escherichia fergusonii strain ATCC 35473

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FV158_RS09135
• Protein ID: WP_148047928.1
• Coordinates: 1871273..1871563 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V0SC69
• Locus tag: FV158_RS09130
• Protein ID: WP_000212715.1
• Coordinates: 1871041..1871283 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FV158_RS09105	1866890..1868263	+	1374	WP_001219809.1	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase	-
FV158_RS09110	1868414..1868965	-	552	WP_000166277.1	ribosome-associated protein	-
FV158_RS09115	1869059..1870411	+	1353	WP_148047927.1	metalloprotease PmbA	-
FV158_RS09120	1870464..1870850	+	387	WP_001232246.1	cytochrome b562	-
FV158_RS09130	1871041..1871283	+	243	WP_000212715.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FV158_RS09135	1871273..1871563	+	291	WP_148047928.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FV158_RS09140	1871564..1872028	-	465	WP_001106232.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
FV158_RS09145	1872213..1874351	-	2139	WP_000187805.1	anaerobic ribonucleoside-triphosphate reductase	-
FV158_RS09150	1874745..1876400	-	1656	WP_148047929.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-72)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11307.26 Da
• Isoelectric Point: 10.2724

>T136665 WP_148047928.1 NZ_CP042942:1871273-1871563 [Escherichia fergusonii]
MNYELAFDPRALKEWQKLGVKVREQFKKKLGDVLKRPRNPSAKLRDLPDCYKIKLRTLGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Nucleotide

• Length: 291 bp

>T136665 NZ_CP042942:1871273-1871563 [Escherichia fergusonii]
ATGAACTATGAACTGGCTTTTGATCCGCGGGCGCTGAAGGAGTGGCAAAAACTGGGCGTGAAAGTCCGGGAACAATTTAA
AAAAAAGCTTGGGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTACGGGATTTGCCGGACTGCTACAAAATTA
AGCTTCGCACACTGGGATATCGCCTGGTCTATCAGGTCAATGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACAAAACGGCTGGATGAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9125.56 Da
• Isoelectric Point: 5.1369

>AT136665 WP_000212715.1 NZ_CP042942:1871041-1871283 [Escherichia fergusonii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Nucleotide

• Length: 243 bp

>AT136665 NZ_CP042942:1871041-1871283 [Escherichia fergusonii]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAGGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A7U9H4B3