Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2826432..2827053 Replicon chromosome
Accession NZ_CP042941
Organism Atlantibacter hermannii strain ATCC 33651

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FV157_RS13285 Protein ID WP_001291435.1
Coordinates 2826432..2826650 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag FV157_RS13290 Protein ID WP_043866710.1
Coordinates 2826679..2827053 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FV157_RS13250 2821952..2822281 + 330 WP_148053090.1 hypothetical protein -
FV157_RS13255 2822654..2822905 + 252 WP_148052435.1 hypothetical protein -
FV157_RS13260 2822902..2823120 + 219 WP_002463728.1 hypothetical protein -
FV157_RS13265 2823259..2824809 - 1551 WP_148052436.1 EAL domain-containing protein -
FV157_RS13270 2825064..2825324 + 261 WP_148052437.1 type B 50S ribosomal protein L31 -
FV157_RS13275 2825327..2825467 + 141 WP_061708247.1 type B 50S ribosomal protein L36 -
FV157_RS13280 2825503..2825970 - 468 WP_002463722.1 YlaC family protein -
FV157_RS13285 2826432..2826650 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
FV157_RS13290 2826679..2827053 - 375 WP_043866710.1 Hha toxicity modulator TomB Antitoxin
FV157_RS13295 2827525..2830673 - 3149 Protein_2550 multidrug efflux RND transporter permease subunit AcrB -
FV157_RS13300 2830696..2831892 - 1197 WP_148052438.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T136646 WP_001291435.1 NZ_CP042941:c2826650-2826432 [Atlantibacter hermannii]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T136646 NZ_CP042941:c2826650-2826432 [Atlantibacter hermannii]
ATGTCAGAAAAACCCTTAACGAAAACTGATTATTTAATGCGTCTACGACGCTGCCAGACTATTGATACGCTTGAAAGAGT
CATTGAAAAAAATAAATACGAATTATCGGATAACGAATTGGCGGTATTTTATTCAGCGGCCGATCACCGTCTTGCCGAGC
TCACAATGAATAAGCTTTACGATAAAATACCATCGTCTGTGTGGAAATTTATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14380.16 Da        Isoelectric Point: 5.1259

>AT136646 WP_043866710.1 NZ_CP042941:c2827053-2826679 [Atlantibacter hermannii]
MDEYSPKRHDIAQLKFLCENLYHDCLITLGDSNHGWVNDPTSAINLQLNELIEHIASFALNYKIKHDEDNALIEHVDEYL
DDTFMLFSNYGISAQDLQKWRKSGNRLFRCFVNVSKANPVSLSF

Download         Length: 375 bp

>AT136646 NZ_CP042941:c2827053-2826679 [Atlantibacter hermannii]
ATGGACGAATACTCACCAAAACGGCATGATATAGCCCAGCTAAAATTCCTGTGTGAAAATCTGTATCATGACTGCCTGAT
AACCCTTGGTGACAGCAATCATGGTTGGGTGAACGATCCAACCTCGGCCATCAACCTGCAGTTAAATGAATTGATTGAGC
ATATTGCGAGTTTTGCGCTTAATTATAAAATTAAGCATGACGAAGATAATGCATTGATCGAACACGTTGATGAGTATCTT
GATGATACCTTCATGCTGTTCAGCAACTATGGTATTAGCGCTCAGGATTTACAGAAATGGCGCAAATCAGGAAACCGTTT
GTTTCGATGTTTCGTCAACGTCAGTAAGGCCAACCCAGTGAGCCTATCTTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References