Detailed information of TA system TA136645

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 1999708..2000294
• Replicon: chromosome
• Accession: NZ_CP042941
• Organism: Atlantibacter hermannii strain ATCC 33651

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: FV157_RS09420
• Protein ID: WP_148052155.1
• Coordinates: 1999926..2000294 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: H5V3H8
• Locus tag: FV157_RS09415
• Protein ID: WP_002436532.1
• Coordinates: 1999708..1999929 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FV157_RS09390	1994791..1995906	+	1116	WP_148052154.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
FV157_RS09395	1995942..1996868	+	927	WP_002436536.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
FV157_RS09400	1996865..1998142	+	1278	WP_002436535.1	high-affinity branched-chain amino acid ABC transporter permease LivM	-
FV157_RS09405	1998139..1998906	+	768	WP_002436534.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
FV157_RS09410	1998908..1999621	+	714	WP_040459930.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
FV157_RS09415	1999708..1999929	+	222	WP_002436532.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FV157_RS09420	1999926..2000294	+	369	WP_148052155.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
FV157_RS09425	2000472..2001785	+	1314	WP_148052156.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
FV157_RS09430	2001846..2002733	+	888	WP_043866379.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
FV157_RS09435	2002730..2003575	+	846	WP_043866380.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
FV157_RS09440	2003585..2004652	+	1068	WP_002436522.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1996865..2005389	8524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (30-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-53)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13528.87 Da
• Isoelectric Point: 9.6220

>T136645 WP_148052155.1 NZ_CP042941:1999926-2000294 [Atlantibacter hermannii]
MTIQFISAEEIIRFHDRLLAVTPGVPGMVDPGRAEALLYRVLNKYEYEGVNDLWLLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGITLPANPAFVGLTVAAAAGQLSLEEIARQLRK

Nucleotide

• Length: 369 bp

>T136645 NZ_CP042941:1999926-2000294 [Atlantibacter hermannii]
ATGACAATTCAGTTTATCTCAGCGGAAGAGATAATTCGTTTTCATGACAGATTGCTGGCCGTCACGCCAGGCGTACCCGG
TATGGTCGATCCGGGTCGGGCGGAAGCACTGTTATACCGTGTGCTTAACAAATACGAGTATGAAGGCGTTAATGACCTCT
GGCTTTTGGCAGCAATGCACCTGCTGGCTATTTCCCGAGGGCATATCTTCAATGATGGCAATAAACGCACGGCGCTGTTT
ATTACGTTGTTGTTCCTTAAGCGCAATGGGATAACACTTCCCGCCAACCCGGCATTTGTCGGGTTAACGGTGGCGGCGGC
GGCAGGGCAACTTAGCCTTGAAGAGATAGCGCGTCAGTTACGAAAGTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8091.20 Da
• Isoelectric Point: 5.6512

>AT136645 WP_002436532.1 NZ_CP042941:1999708-1999929 [Atlantibacter hermannii]
MQTMNYSEARQNLAAALETAALGTPVTITRRGHKPAVIISAEEFERYQQAKMDAEFAAIMAIHGNEIRELADK

Nucleotide

• Length: 222 bp

>AT136645 NZ_CP042941:1999708-1999929 [Atlantibacter hermannii]
ATGCAAACCATGAACTATAGCGAAGCGCGCCAGAATCTTGCTGCCGCGCTCGAGACTGCTGCGCTGGGTACGCCTGTCAC
TATCACCCGTCGGGGCCACAAACCTGCGGTAATTATTAGCGCCGAAGAATTCGAACGTTATCAACAAGCAAAGATGGATG
CCGAATTTGCCGCCATCATGGCTATTCATGGCAATGAAATCAGGGAACTTGCCGATAAATGA

Structures

Antitoxin

• AlphaFold DB: H5V3H8