Detailed information of TA system TA136643

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 949459..950926
• Replicon: chromosome
• Accession: NZ_CP042938
• Organism: Mycoplasma bovis strain MJ1

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: Q932V7
• Locus tag: CH329_RS04065
• Protein ID: WP_041309184.1
• Coordinates: 949459..950319 (-)
• Length: 287 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: Q934C3
• Locus tag: CH329_RS04070
• Protein ID: WP_013456322.1
• Coordinates: 950312..950926 (-)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH329_RS04045	945472..946479	+	1008	WP_075270934.1	ECF transporter S component	-
CH329_RS04050	947028..947672	+	645	WP_167662357.1	variable surface lipoprotein	-
CH329_RS04055	947848..948408	+	561	WP_167662358.1	variable surface lipoprotein	-
CH329_RS04060	949225..949338	-	114	Protein_771	variable surface lipoprotein	-
CH329_RS04065	949459..950319	-	861	WP_041309184.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
CH329_RS04070	950312..950926	-	615	WP_013456322.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
CH329_RS04075	951109..951222	+	114	Protein_774	variable surface lipoprotein	-
CH329_RS04080	952164..952721	+	558	WP_167662359.1	variable surface lipoprotein	-
CH329_RS04085	952764..953495	-	732	WP_075275861.1	variable surface lipoprotein	-
CH329_RS04465	953671..954384	-	714	WP_198911677.1	variable surface lipoprotein	-
CH329_RS04095	954568..955181	+	614	Protein_778	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	944143..945261	1118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-234)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (13-59)

Sequences

Toxin

Protein

• Length: 287 a.a.
• Molecular weight: 33281.35 Da
• Isoelectric Point: 7.2878

>T136643 WP_041309184.1 NZ_CP042938:c950319-949459 [Mycoplasma bovis]
MNKNKLISLCHKTADENNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Nucleotide

• Length: 861 bp

>T136643 NZ_CP042938:c950319-949459 [Mycoplasma bovis]
ATGAATAAAAATAAATTAATAAGTTTGTGTCATAAAACTGCTGATGAAAATAACGCAAATTTCAATGTTGTTTTAATTCA
ATATTTTATGGAAAGCATTCTACGAAGAATATCTAAAAGTAATGAGAGAGACAATTTTGTGTTCAAGGGCGGTTTTCTTT
TATCTAACATTATGGGGTTAGATAAAAGAGCTACAATGGATATTGATTTGGAGCTAATAAAAACTCAAAAGATAAGTGCT
TCTAAAATATTAGAAAAATTTAAAAGTATATTAAACGCTGATGACATCGATGGAATTAGATATCACATTCTTAAGTATAC
TGACATTCGAAAGGAGCATAAATATAGTGGCATTAACATATCAGTCCTATGTCAAATAGAGAATATAAAACAAGTTATTT
CTATAGATATTGCATCAGGCGATGTCATTACACCTAAGGAAATTGTTTATGAATACAAAAGTATATTTTCAAATCAGGAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTATCTGAAAAGCTTGAGACAATATTTTCTTTTGGTCACTTAAATAC
AAGATTTAAAGATTTTTATGATGTTTATGTTATATACACTTTTAAAAAGAAGGACATTGATATTAATAGGCTCAAGGATG
CTTGCTATAACACATTCAAAAATAGGAACAGTGAATTTAACATACAACAATTGTTGGAACTAATTACCAATATTGCTTTC
AATCCGTTGATGAATGAAAGATGAAAAAAGTACATAAGTCAGATAGCAAATCAGCAGGAAATAGACTTTAAAGCCATTAC
TAATTCAATAATAGAACTACTAGAACTAATTAAGGTCAATGAATTAACAAATAATGATTAA

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 24143.83 Da
• Isoelectric Point: 9.7617

>AT136643 WP_013456322.1 NZ_CP042938:c950926-950312 [Mycoplasma bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Nucleotide

• Length: 615 bp

>AT136643 NZ_CP056160:51495-51698 [Escherichia marmotae]
ATGAGAACTACTGTAACGATCGACGATGCTCTGTACGCACAGGCGCTGGAAATGGCTGATCCAGGCATGGATAAATCAGA
TATTTTCCGTGAAGCTGTGAAAACGTTTATTCGTGTGCAGGCTGCGAAACGCCTGGCTTCACTTGGCGGAACAGCCCCGG
ATATGGAGATAACACCACGCAGGCGTGGAGATGTGGCGGAATGA

Structures

Toxin

• AlphaFold DB: Q932V7

Antitoxin

• AlphaFold DB: Q934C3