Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3039386..3040040 Replicon chromosome
Accession NZ_CP042934
Organism Escherichia coli 042

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag FVF73_RS14815 Protein ID WP_000244777.1
Coordinates 3039386..3039793 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag FVF73_RS14820 Protein ID WP_000354046.1
Coordinates 3039774..3040040 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVF73_RS14795 3035343..3037076 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
FVF73_RS14800 3037082..3037792 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FVF73_RS14805 3037817..3038713 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
FVF73_RS14810 3038825..3039346 + 522 WP_001055874.1 flavodoxin FldB -
FVF73_RS14815 3039386..3039793 - 408 WP_000244777.1 toxin CptA Toxin
FVF73_RS14820 3039774..3040040 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
FVF73_RS14825 3040283..3041263 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
FVF73_RS14830 3041340..3041999 - 660 WP_000250274.1 hemolysin III family protein -
FVF73_RS14835 3042163..3042474 - 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
FVF73_RS14840 3042519..3043952 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
FVF73_RS14845 3044009..3044752 - 744 Protein_2858 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T136634 WP_000244777.1 NZ_CP042934:c3039793-3039386 [Escherichia coli 042]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T136634 NZ_CP042934:c3039793-3039386 [Escherichia coli 042]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT136634 WP_000354046.1 NZ_CP042934:c3040040-3039774 [Escherichia coli 042]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT136634 NZ_CP042934:c3040040-3039774 [Escherichia coli 042]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References