Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3893556..3894216 Replicon chromosome
Accession NZ_CP042930
Organism Leclercia adecarboxylata strain J656

Toxin (Protein)


Gene name cptA Uniprot ID A0A7H0FEK5
Locus tag FTX45_RS18450 Protein ID WP_032613858.1
Coordinates 3893556..3893969 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G7TIV6
Locus tag FTX45_RS18455 Protein ID WP_032613860.1
Coordinates 3893950..3894216 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTX45_RS18430 3889554..3891287 - 1734 WP_150872384.1 single-stranded-DNA-specific exonuclease RecJ -
FTX45_RS18435 3891293..3892006 - 714 WP_032613852.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FTX45_RS18440 3892032..3892928 - 897 WP_032613854.1 site-specific tyrosine recombinase XerD -
FTX45_RS18445 3893030..3893551 + 522 WP_117386687.1 flavodoxin FldB -
FTX45_RS18450 3893556..3893969 - 414 WP_032613858.1 protein YgfX Toxin
FTX45_RS18455 3893950..3894216 - 267 WP_032613860.1 FAD assembly factor SdhE Antitoxin
FTX45_RS18460 3894521..3895501 + 981 WP_144839541.1 tRNA-modifying protein YgfZ -
FTX45_RS18465 3895631..3896290 - 660 WP_032613865.1 hemolysin III family protein -
FTX45_RS18470 3896456..3896767 - 312 WP_032613867.1 N(4)-acetylcytidine aminohydrolase -
FTX45_RS18475 3896820..3897551 + 732 WP_032613869.1 MurR/RpiR family transcriptional regulator -
FTX45_RS18480 3897664..3899097 + 1434 WP_032613871.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16231.98 Da        Isoelectric Point: 10.6531

>T136617 WP_032613858.1 NZ_CP042930:c3893969-3893556 [Leclercia adecarboxylata]
VVLWQSDLRVSWRAQWMSLLLHGLVAACILLIPWPLSYTPLWLILLSLVVFDSVRSQRRINSRQGEIKLFMDSRLQWQGS
EWEIIGTPWMLNSGMMLRLRKGDGKRYQHLWLSADSMDEGEWRDLRRMLSQQPTHGR

Download         Length: 414 bp

>T136617 NZ_CP042930:c3893969-3893556 [Leclercia adecarboxylata]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCCCAGTGGATGTCTCTTTTGCTCCACGGCCTGGTTGCGGC
TTGCATCCTGTTGATACCATGGCCGCTAAGCTACACCCCGTTATGGTTAATTTTACTGTCGCTGGTGGTGTTTGACAGCG
TACGCAGCCAACGGCGCATCAATTCCCGTCAGGGCGAAATCAAGCTGTTCATGGATTCCCGCCTGCAGTGGCAGGGTAGC
GAGTGGGAGATTATCGGTACGCCGTGGATGCTCAATTCCGGCATGATGCTCCGCTTACGCAAGGGCGACGGGAAACGCTA
CCAGCATTTGTGGTTGTCGGCAGACAGCATGGATGAAGGGGAGTGGCGGGATCTGCGCCGGATGCTTTCGCAGCAACCGA
CGCACGGGCGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10539.06 Da        Isoelectric Point: 4.6787

>AT136617 WP_032613860.1 NZ_CP042930:c3894216-3893950 [Leclercia adecarboxylata]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKKLFIRLLENDDPDLFNWLMNHGEPADAELQRMVLLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT136617 NZ_CP056155:c2023247-2022981 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACAGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTATGCCGAGTTCATTGACATGCTCGATGCCCCGGTCGCGAACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCGCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0FEK5

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7TIV6

References