Detailed information of TA system TA136607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 2315445..2316019
• Replicon: chromosome
• Accession: NZ_CP042930
• Organism: Leclercia adecarboxylata strain J656

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FTX45_RS11110
• Protein ID: WP_150870942.1
• Coordinates: 2315693..2316019 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FTX45_RS11105
• Protein ID: WP_150870940.1
• Coordinates: 2315445..2315693 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FTX45_RS11090	2312349..2313893	+	1545	WP_150870931.1	nitrate reductase subunit beta	-
FTX45_RS11095	2313893..2314588	+	696	WP_150870934.1	nitrate reductase molybdenum cofactor assembly chaperone	-
FTX45_RS11100	2314585..2315265	+	681	WP_150870937.1	respiratory nitrate reductase subunit gamma	-
FTX45_RS11105	2315445..2315693	+	249	WP_150870940.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FTX45_RS11110	2315693..2316019	+	327	WP_150870942.1	endoribonuclease MazF	Toxin
FTX45_RS11115	2316048..2316893	-	846	WP_059307893.1	N-hydroxyarylamine O-acetyltransferase	-
FTX45_RS11120	2317090..2318745	-	1656	WP_130588826.1	iron ABC transporter permease	-
FTX45_RS11125	2318784..2319752	-	969	WP_032618179.1	ABC transporter substrate-binding protein	-
FTX45_RS11130	2319749..2320441	-	693	WP_150870945.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-107)

Antitoxin

• Antitoxin PemI-like (4-81)

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11891.60 Da
• Isoelectric Point: 7.2430

>T136607 WP_150870942.1 NZ_CP042930:2315693-2316019 [Leclercia adecarboxylata]
MDYIPEAGDIVWLDFDPQSGHEQAGHRPALVVSPATYNGRTGLMLCCPVTSQIKNYPFEVVISGARRNVALADQIKSLDW
RARHAEKKGTATAEELDAVRMRAKVLIG

Nucleotide

• Length: 327 bp

>T136607 NZ_CP042930:2315693-2316019 [Leclercia adecarboxylata]
ATGGACTACATCCCGGAAGCGGGCGATATCGTCTGGCTGGATTTTGATCCGCAGTCAGGTCATGAACAGGCAGGCCATCG
CCCTGCGCTGGTTGTTTCCCCCGCCACTTACAATGGACGCACCGGTCTGATGCTCTGCTGTCCAGTCACGTCGCAAATCA
AAAACTACCCCTTCGAAGTTGTCATTAGCGGAGCACGCCGCAATGTCGCCCTCGCCGATCAGATCAAAAGTCTGGACTGG
CGCGCGCGTCACGCAGAGAAAAAGGGAACGGCAACTGCCGAAGAACTGGATGCCGTGAGAATGCGGGCGAAGGTTTTGAT
CGGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9149.45 Da
• Isoelectric Point: 4.7724

>AT136607 WP_150870940.1 NZ_CP042930:2315445-2315693 [Leclercia adecarboxylata]
MPQVTVKKWGNSPSVRLPVAVMREAELHIDDVVNVNVDEEGRIILTPVRKNEPTLESLLAAITDDNLHHEVTFGQPQGKE
LL

Nucleotide

• Length: 249 bp

>AT136607 NZ_CP056155:47808-48134 [Enterobacter hormaechei]
ATGTCATTAATACCAGCCCATGAATGGGGACTACAAAGAGAAATTGTTCCACGGTTTGGTGCCAGATTAGTTCAGGAAGG
CAACCGGCTGCATTATCTGGCTGACAGGGCTAGTTTGATGGGCAATTTCAGCGATACGGAATGTTTCAAATTGAATGACG
CATTTCCACACTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAACTGATCCCCTGTCACCATCACTGTGTCACT
CTCTACCACAACGGTTTTACCTGCGAAGCTGACACCCTTGGCAGTTGCGGCTACGTGTACATCGCTGTTTACCCCACTCA
ACGCTAA