Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2237331..2238896 Replicon chromosome
Accession NZ_CP042930
Organism Leclercia adecarboxylata strain J656

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FTX45_RS10785 Protein ID WP_150870856.1
Coordinates 2237331..2238641 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FTX45_RS10790 Protein ID WP_032618098.1
Coordinates 2238645..2238896 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTX45_RS10770 2232812..2233993 - 1182 WP_032618094.1 PLP-dependent aminotransferase family protein -
FTX45_RS10775 2234126..2236123 - 1998 WP_117386533.1 TonB-dependent receptor -
FTX45_RS10780 2236134..2237195 - 1062 WP_150870854.1 YncE family protein -
FTX45_RS10785 2237331..2238641 - 1311 WP_150870856.1 type II toxin-antitoxin system HipA family toxin Toxin
FTX45_RS10790 2238645..2238896 - 252 WP_032618098.1 helix-turn-helix domain-containing protein Antitoxin
FTX45_RS10795 2239696..2243496 + 3801 WP_150870858.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48254.39 Da        Isoelectric Point: 6.5044

>T136606 WP_150870856.1 NZ_CP042930:c2238641-2237331 [Leclercia adecarboxylata]
MRAQRLTVAMNGDVVGTLHRDGSGAMSFQYAPEWLAEPGSRAISLSLPLQHGRIRGAQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGQEIPPVTDIVAEPLDDDQIAALLDGYQMAPLGMTEEDADFRISLAGAQEKT
ALLWYQSRWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAQAEMATFGRKKVLIIERFDRRW
SSSGWLMRLPQEDFCQALGVSPALKYESHGGPGIADAMKLLLGSRLAGQDRELFFKAQILFWMLAAIDGHGKNFSLFIEP
DSAFRMAPLYDVISAFPLFDAGGIPVKKAKMAMALQGKNRQYHFAMIQPRHFISTAAFAGYSQEAARRLLTEMAERTDDV
IASVRAELPPDFPAQVSEAIFKGLASQAARIGRFVS

Download         Length: 1311 bp

>T136606 NZ_CP042930:c2238641-2237331 [Leclercia adecarboxylata]
ATGCGCGCACAACGACTGACTGTCGCGATGAATGGCGACGTAGTGGGGACGCTGCATCGTGACGGCAGCGGGGCAATGTC
CTTCCAGTATGCCCCGGAATGGCTGGCCGAGCCGGGTTCGCGCGCGATTTCGCTCTCTTTGCCGCTACAGCACGGCAGGA
TCAGAGGCGCGCAGGTCTTTAATTTCTTCAGTAATCTGCTGCCTGACTCTGAGGCGATTATTGCCCGCATGCAGGCCCGA
TTCCAGGTTGAAACCGCTCATCCCTTTGATCTGCTGGCCAGTGTCGGGCGTGACTGTGTGGGTGCCATTCAGCTCTATCC
GCCGGGACAGGAGATCCCCCCGGTAACGGATATCGTGGCGGAACCGCTGGATGACGATCAGATTGCCGCGTTGCTCGACG
GGTATCAGATGGCACCGCTGGGGATGACCGAGGAGGATGCCGACTTTCGCATTTCGCTGGCCGGCGCGCAGGAAAAGACG
GCGCTGCTGTGGTACCAGTCGCGATGGCAGCGGCCCCAGGGTAGCACCCCAACCAGTCATATCTTTAAGCTGCCGATCGG
CAGAATAGAACAAAACAATATCGACCTGAGCGAAAGTTGTGAAAACGAATGGCTGTGTTTGCGCATTGCCAAAGCCTTTG
GTTTCCCAGTGGCACAGGCTGAGATGGCAACCTTTGGCCGCAAGAAAGTGCTGATTATCGAGCGTTTCGACCGTCGCTGG
TCCAGCAGCGGGTGGCTGATGCGCCTGCCGCAGGAAGATTTTTGCCAGGCCCTGGGCGTGTCGCCAGCGCTGAAATATGA
ATCTCACGGTGGTCCCGGGATTGCCGACGCCATGAAGCTGCTGCTCGGCTCCCGCCTGGCGGGGCAGGATCGCGAGCTGT
TCTTTAAGGCGCAGATCCTGTTCTGGATGCTGGCCGCCATTGATGGTCACGGGAAGAATTTCAGCCTGTTTATCGAGCCG
GATTCCGCCTTTCGCATGGCCCCGCTGTACGACGTGATTTCCGCGTTTCCGCTGTTCGACGCAGGGGGGATCCCGGTCAA
AAAAGCGAAGATGGCGATGGCGTTACAGGGCAAGAACCGGCAGTACCATTTTGCGATGATCCAACCGCGTCACTTTATTA
GCACCGCTGCTTTTGCAGGTTATTCCCAGGAGGCCGCTCGCCGTTTGCTGACTGAGATGGCGGAGCGAACAGACGACGTT
ATTGCCTCCGTCAGGGCAGAATTGCCACCGGATTTCCCCGCGCAGGTCAGTGAGGCCATTTTTAAGGGGTTAGCCAGCCA
GGCGGCAAGAATAGGGCGATTCGTGAGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9223.56 Da        Isoelectric Point: 10.1945

>AT136606 WP_032618098.1 NZ_CP042930:c2238896-2238645 [Leclercia adecarboxylata]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSEFENKPGSTKLETLFKILSALDLELHVVKRGGTLPDNNAWK
KEW

Download         Length: 252 bp

>AT136606 NZ_CP042930:c2238896-2238645 [Leclercia adecarboxylata]
ATGAAAGTTACATCGGCAGACGCACTGGCTCAGGCTGTCCGGGATCAGCGTAAGGTCAATAAGTTAACCCAAACGGCAAC
GGCTGAACAGGTGGGGATTAAACAAACCACGGTATCGGAATTTGAGAACAAACCAGGCTCTACCAAACTGGAAACCTTGT
TCAAAATCCTCTCGGCGCTGGATCTGGAGCTGCACGTGGTGAAACGAGGCGGCACGTTGCCGGATAACAATGCCTGGAAG
AAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References