Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1352717..1353353 Replicon chromosome
Accession NZ_CP042930
Organism Leclercia adecarboxylata strain J656

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag FTX45_RS06375 Protein ID WP_150872787.1
Coordinates 1352988..1353353 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag FTX45_RS06370 Protein ID WP_150870274.1
Coordinates 1352717..1352947 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTX45_RS06345 1348492..1349612 + 1121 WP_103278593.1 IS3-like element ISSen4 family transposase -
FTX45_RS06350 1349659..1351047 - 1389 WP_150870267.1 DEAD/DEAH box helicase family protein -
FTX45_RS06355 1351041..1351610 - 570 WP_150870269.1 hypothetical protein -
FTX45_RS06360 1351709..1352020 + 312 WP_150870270.1 helix-turn-helix domain-containing protein -
FTX45_RS06365 1352122..1352340 - 219 WP_150870272.1 hypothetical protein -
FTX45_RS06370 1352717..1352947 + 231 WP_150870274.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FTX45_RS06375 1352988..1353353 + 366 WP_150872787.1 PIN domain-containing protein Toxin
FTX45_RS06380 1353571..1354338 + 768 WP_150870276.1 hypothetical protein -
FTX45_RS06385 1354408..1355076 + 669 WP_150870278.1 response regulator -
FTX45_RS06390 1355052..1356401 + 1350 WP_150870280.1 sensor histidine kinase -
FTX45_RS06395 1356615..1357091 - 477 WP_150870282.1 WbuC family cupin fold metalloprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 12905.93 Da        Isoelectric Point: 7.1676

>T136605 WP_150872787.1 NZ_CP042930:1352988-1353353 [Leclercia adecarboxylata]
MREQPEAVLKRLEQAVLRNQRIVISAISWSEISLAARAAGPATQQLANAFCARLDAILPWDRGAVDATTDIKVALRLAGT
TIGPNHTLIAGHAIAAGAVLVTMKGGEFERVPGLVLEDWVN

Download         Length: 366 bp

>T136605 NZ_CP042930:1352988-1353353 [Leclercia adecarboxylata]
ATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCTGGAGCAGGCGGTACTGCGCAACCAGCGCATCGTGATCTCGGCCAT
ATCCTGGTCTGAGATTTCACTGGCCGCCCGGGCTGCGGGGCCTGCCACACAGCAGCTGGCTAACGCGTTCTGCGCCCGCC
TCGATGCCATCCTGCCCTGGGACCGCGGCGCGGTGGATGCGACCACGGATATTAAGGTGGCGTTGCGCCTCGCCGGGACG
ACGATCGGCCCGAATCACACATTGATTGCCGGGCACGCCATTGCTGCCGGCGCCGTACTGGTGACAATGAAAGGGGGGGA
GTTTGAGCGGGTGCCGGGCCTGGTGCTGGAAGACTGGGTTAACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8663.88 Da        Isoelectric Point: 4.8011

>AT136605 WP_150870274.1 NZ_CP042930:1352717-1352947 [Leclercia adecarboxylata]
MRTVSIFKNGNNRAIRLPRNLDIEGVSELEIVREGDRIILRPVRPIWGSFAQLEKADPDFMAERGDVVTDEGRVDL

Download         Length: 231 bp

>AT136605 NZ_CP042930:1352717-1352947 [Leclercia adecarboxylata]
ATGAGAACCGTATCCATTTTTAAAAACGGCAATAACCGCGCCATCCGTCTTCCCCGCAATCTGGATATTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACCGTATTATCCTGCGTCCCGTCCGCCCGATCTGGGGCTCGTTCGCGCAGCTGG
AAAAAGCCGACCCGGACTTTATGGCGGAGCGCGGGGACGTTGTCACCGACGAAGGACGGGTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References