Detailed information of TA system TA136596

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 5858438..5859224
• Replicon: chromosome
• Accession: NZ_CP042911
• Organism: Gemmata obscuriglobus strain DSM 5831

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: GobsT_RS24455
• Protein ID: WP_010037297.1
• Coordinates: 5858438..5858872 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: GobsT_RS38110
• Protein ID: WP_010037295.1
• Coordinates: 5858880..5859224 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GobsT_RS24450	5854934..5857597	-	2664	WP_010037300.1	FkbM family methyltransferase	-
GobsT_RS24455	5858438..5858872	-	435	WP_010037297.1	PIN domain-containing protein	Toxin
GobsT_RS38110	5858880..5859224	-	345	WP_010037295.1	excisionase family DNA-binding protein	Antitoxin
GobsT_RS38115	5859226..5859417	+	192	WP_010037292.1	hypothetical protein	-
GobsT_RS24465	5860138..5860659	+	522	WP_010037290.1	DUF3050 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• SinI-like, DNA-binding domain (45-89)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16615.84 Da
• Isoelectric Point: 6.2238

>T136596 WP_010037297.1 NZ_CP042911:c5858872-5858438 [Gemmata obscuriglobus]
VSNFTALYDTCVLHLAPLRDFLMSRAEAKMFRARWTERIHEEWTRSLLEAANRPNPREARTHAAVDGCRGARLPHLRYED
LIDGLELPDPDDRQVLAATIRGRVDVIVMLNLKDFPPERRSPFGIEAHYPDVFIDHQLSLNQSD

Nucleotide

• Length: 435 bp

>T136596 NZ_CP056150:2200112-2200465 [Klebsiella grimontii]
GTGTGGATGATTAAAACAACGGATACGTTTGAGCGCTGGTTTACCTCGCTCAACGATACCGATAGGGCCAGGGTGCTTGC
AGCGTTGTTGGTCCTGCGAGAAAAGGGGCCGGGTTTGTCCAGACCGTATGCCGATACGCTGAGAGGCTCCCGCTACAGCA
ACATGAAAGAGTTGCGTATTCAGAGCCGGGGCGAGCCGATACGGGCATTTTTCGCTTTTGGCCCGGCCCGTACCGGCATT
GTGCTTTGTGCCGGTAATAAGGTTGGCAATGAAAAACGTTTTTACGATGAGATGCTCCCTGTTGCTGAGCGGGAATTCAC
GAACTGGCTGAAGACATTCAAAGAGAAGGAGTAA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12649.44 Da
• Isoelectric Point: 6.0845

>AT136596 WP_010037295.1 NZ_CP042911:c5859224-5858880 [Gemmata obscuriglobus]
VAVQENGKPGDVVAVSMAAFRLFTDILNAMARGDAGTIIPLHAELTTQQAADLLNVSRRYLVKLLERDEPSYHMVGTHRR
IKFHDLMAYSRVADEKRRQALDALAEEGEELGMG

Nucleotide

• Length: 345 bp

>AT136596 NZ_CP042911:c5859224-5858880 [Gemmata obscuriglobus]
GTGGCCGTTCAGGAGAACGGGAAACCGGGCGACGTGGTGGCAGTGTCGATGGCCGCGTTCCGGCTGTTCACTGACATCCT
CAACGCGATGGCCCGCGGCGACGCGGGCACTATCATACCGCTGCACGCCGAGTTGACTACGCAACAGGCTGCAGACCTGC
TGAACGTGTCGCGCCGGTACCTCGTGAAACTGCTGGAGCGCGACGAACCGTCCTATCACATGGTCGGCACCCACCGACGA
ATCAAGTTCCACGACCTCATGGCATACTCTCGGGTCGCGGATGAGAAGCGGCGGCAGGCGCTCGACGCGCTGGCCGAAGA
GGGAGAAGAACTCGGAATGGGGTAA