Detailed information of TA system TA136595

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3902498..3903197
• Replicon: chromosome
• Accession: NZ_CP042907
• Organism: Proteus mirabilis strain VAC

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: FVP19_RS18225
• Protein ID: WP_004249093.1
• Coordinates: 3902498..3902884 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: FVP19_RS18230
• Protein ID: WP_004246828.1
• Coordinates: 3902877..3903197 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVP19_RS18210	3898511..3899092	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
FVP19_RS18215	3899343..3900248	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
FVP19_RS18220	3900258..3902330	+	2073	WP_017827114.1	glycine--tRNA ligase subunit beta	-
FVP19_RS18225	3902498..3902884	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FVP19_RS18230	3902877..3903197	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
FVP19_RS18235	3903248..3903682	-	435	WP_004246827.1	hypothetical protein	-
FVP19_RS18240	3903675..3904559	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
FVP19_RS18245	3904776..3906062	-	1287	WP_004246824.1	DUF3748 domain-containing protein	-
FVP19_RS18250	3906199..3906816	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
FVP19_RS18255	3907118..3907741	+	624	WP_004246821.1	guanylate kinase	-
FVP19_RS18260	3907796..3908071	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T136595 WP_004249093.1 NZ_CP042907:3902498-3902884 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T136595 NZ_CP042907:3902498-3902884 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT136595 WP_004246828.1 NZ_CP042907:3902877-3903197 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT136595 NZ_CP042907:3902877-3903197 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGTATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTTCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97