Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3458404..3460126 Replicon chromosome
Accession NZ_CP042907
Organism Proteus mirabilis strain VAC

Toxin (Protein)


Gene name mosT Uniprot ID A0A6N4MEU3
Locus tag FVP19_RS16235 Protein ID WP_004249362.1
Coordinates 3458404..3459342 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A6G6SM63
Locus tag FVP19_RS16240 Protein ID WP_036973704.1
Coordinates 3459335..3460126 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVP19_RS16215 3454345..3454857 - 513 WP_004249367.1 S26 family signal peptidase -
FVP19_RS16220 3454841..3455188 - 348 WP_004249366.1 hypothetical protein -
FVP19_RS16225 3455181..3457580 - 2400 WP_004249365.1 type IV secretion system protein TraC -
FVP19_RS16230 3457580..3458272 - 693 WP_004249363.1 DsbC family protein -
FVP19_RS16235 3458404..3459342 - 939 WP_004249362.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
FVP19_RS16240 3459335..3460126 - 792 WP_036973704.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
FVP19_RS16245 3460347..3460733 - 387 WP_004249359.1 hypothetical protein -
FVP19_RS16250 3460730..3461302 - 573 WP_004249358.1 type IV conjugative transfer system lipoprotein TraV -
FVP19_RS16255 3461377..3462666 - 1290 WP_004249357.1 TraB/VirB10 family protein -
FVP19_RS16260 3462669..3463565 - 897 WP_004249356.1 type-F conjugative transfer system secretin TraK -
FVP19_RS16265 3463549..3464175 - 627 WP_004249355.1 type IV conjugative transfer system protein TraE -
FVP19_RS16270 3464172..3464453 - 282 WP_004249354.1 type IV conjugative transfer system protein TraL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(J) - 3362811..3526671 163860


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35569.83 Da        Isoelectric Point: 5.1159

>T136594 WP_004249362.1 NZ_CP042907:c3459342-3458404 [Proteus mirabilis]
MDKDSPYYKQVSLLIRLLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRNEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQHLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T136594 NZ_CP042907:c3459342-3458404 [Proteus mirabilis]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGACTGCTTCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAAATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATCGTTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGAAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGATTTCGAGAGAGATTTTGGTGGGTTTTTTAACCTA
TACATTAAGTCACCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCATCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCCATGATGTTAATTGAACTGCAAAAA
CATTTCACAGAAAGGGATCATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAGTTGCAGAACATTAACAAATTGGCAAAGAATCAAGCAAAACATCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30113.48 Da        Isoelectric Point: 9.5097

>AT136594 WP_036973704.1 NZ_CP042907:c3460126-3459335 [Proteus mirabilis]
MSSKINWLIAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp

>AT136594 NZ_CP042907:c3460126-3459335 [Proteus mirabilis]
ATGTCATCTAAAATAAACTGGCTTATTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTGGATGTGCAATTGGGCGTTTCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTACAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGTGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAGGATTTGAAAAGGATCACGGTTAAAGAGAAAGAACTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGTGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N4MEU3

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6SM63

References