Detailed information of TA system TA136593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 3303632..3304653
• Replicon: chromosome
• Accession: NZ_CP042907
• Organism: Proteus mirabilis strain VAC

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: FVP19_RS15590
• Protein ID: WP_004249488.1
• Coordinates: 3304084..3304653 (+)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: B4F2H3
• Locus tag: FVP19_RS15585
• Protein ID: WP_004245528.1
• Coordinates: 3303632..3304084 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVP19_RS15565	3299418..3299948	-	531	WP_004245524.1	RNA pyrophosphohydrolase	-
FVP19_RS15570	3300217..3301230	+	1014	WP_004250228.1	thiamine ABC transporter substrate binding subunit	-
FVP19_RS15575	3301230..3302810	+	1581	WP_004245526.1	thiamine/thiamine pyrophosphate ABC transporter permease ThiP	-
FVP19_RS15580	3302803..3303504	+	702	WP_004245527.1	thiamine ABC transporter ATP-binding protein ThiQ	-
FVP19_RS15585	3303632..3304084	+	453	WP_004245528.1	helix-turn-helix domain-containing protein	Antitoxin
FVP19_RS15590	3304084..3304653	+	570	WP_004249488.1	PIN domain-containing protein	Toxin
FVP19_RS15595	3304769..3307123	+	2355	WP_071425514.1	DNA polymerase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-113)

Antitoxin

• SinI-like, DNA-binding domain (80-125)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21600.10 Da
• Isoelectric Point: 7.3470

>T136593 WP_004249488.1 NZ_CP042907:3304084-3304653 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Nucleotide

• Length: 570 bp

>T136593 NZ_CP056150:738954-739331 [Klebsiella grimontii]
ATGCAAACACAACCTGTTCCCCCGACACAGGAGGCTTCACCACGCCCGTCACCAGTGGAGATCTGGCTCCGCCTTTTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGTTAAACGACACGCCATTTTGCAATGATGGTGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGCCCTGATACGCACCGATCGTCACGGTTTC
AGCGCAGAAACACAGTCCCCACTCATCAGCAGTATTGATATCCTTCGCGCCCGTAAGGCCTGTGGACTGATGGCACGCAA
TGGCTACAGACTGGTGACCGATATCACCACCGGCAAATACAGCGAGGTGACTCGATGA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16700.15 Da
• Isoelectric Point: 5.7723

>AT136593 WP_004245528.1 NZ_CP042907:3303632-3304084 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Nucleotide

• Length: 453 bp

>AT136593 NZ_CP056150:738578-738904 [Klebsiella grimontii]
ATCGCCGAACCCTGGTGGGGGCTTAAACGCGATATCACACCCTGTTTTGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGCCGACCGCGCCAGTATCACCGGGCAGTTCAGCGACGCGGATTTACGCCATCTGGACCAGGCATTTCCGC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCCGCCATCAGCACGGCGTCACGCTCTACGCA
AAAGGGCTGACCTGCAACGCGGATACACTCGGCAGTTGCGGATATGTCTATATAGCGATTTACCCGACACCTGCAACAAC
AGAATAA

Structures

Antitoxin

• AlphaFold DB: B4F2H3