Detailed information of TA system TA136592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 137218..137819
• Replicon: chromosome
• Accession: NZ_CP042907
• Organism: Proteus mirabilis strain VAC

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: FVP19_RS00595
• Protein ID: WP_017826987.1
• Coordinates: 137218..137601 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: FVP19_RS00600
• Protein ID: WP_004246496.1
• Coordinates: 137598..137819 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVP19_RS00575	133150..133713	+	564	WP_012368640.1	methyltransferase	-
FVP19_RS00580	133989..134888	+	900	WP_004246500.1	N-acetylmuramic acid 6-phosphate etherase	-
FVP19_RS00585	135245..136483	-	1239	WP_004246499.1	HipA domain-containing protein	-
FVP19_RS00590	136496..136810	-	315	WP_004246498.1	helix-turn-helix domain-containing protein	-
FVP19_RS00595	137218..137601	-	384	WP_017826987.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
FVP19_RS00600	137598..137819	-	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FVP19_RS00605	138041..138904	-	864	WP_004249947.1	YicC family protein	-
FVP19_RS00610	139031..139747	+	717	WP_071425439.1	ribonuclease PH	-
FVP19_RS00615	139829..140473	+	645	WP_004246493.1	orotate phosphoribosyltransferase	-
FVP19_RS00620	140792..141397	-	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
FVP19_RS00625	141517..141975	-	459	WP_004246490.1	dUTP diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14481.57 Da
• Isoelectric Point: 8.5125

>T136592 WP_017826987.1 NZ_CP042907:c137601-137218 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMPDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T136592 NZ_CP042907:c137601-137218 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGCC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT136592 WP_004246496.1 NZ_CP042907:c137819-137598 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT136592 NZ_CP056149:c141506-141240 [Enterobacter roggenkampii]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9