Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/doc-MazF
Location 3089755..3090339 Replicon chromosome
Accession NZ_CP042905
Organism Candidatus Prometheoarchaeum syntrophicum strain MK-D1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DSAG12_RS13930 Protein ID WP_147665270.1
Coordinates 3089755..3090000 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DSAG12_RS13935 Protein ID WP_162306862.1
Coordinates 3090022..3090339 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSAG12_RS13895 (DSAG12_02808) 3085498..3086250 + 753 WP_162306737.1 4Fe-4S binding protein -
DSAG12_RS13900 3086482..3086721 - 240 WP_147663901.1 hypothetical protein -
DSAG12_RS13905 (DSAG12_02809) 3086737..3086937 - 201 WP_147663902.1 hypothetical protein -
DSAG12_RS13910 (DSAG12_02810) 3087108..3087935 + 828 WP_147663903.1 aldo/keto reductase -
DSAG12_RS13915 (DSAG12_02811) 3087990..3088787 + 798 WP_147663904.1 CPBP family intramembrane metalloprotease -
DSAG12_RS13920 (DSAG12_02812) 3088820..3089242 - 423 WP_244626268.1 nuclear transport factor 2 family protein -
DSAG12_RS13930 (DSAG12_02814) 3089755..3090000 + 246 WP_147665270.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
DSAG12_RS13935 (DSAG12_02815) 3090022..3090339 + 318 WP_162306862.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
DSAG12_RS13940 (DSAG12_02817) 3090984..3092429 - 1446 WP_147663906.1 RsmB/NOP family class I SAM-dependent RNA methyltransferase -
DSAG12_RS13945 (DSAG12_02818) 3092809..3093267 + 459 WP_244626269.1 DUF4442 domain-containing protein -
DSAG12_RS13950 (DSAG12_02819) 3093667..3094104 - 438 WP_147663908.1 hypothetical protein -
DSAG12_RS19885 (DSAG12_02820) 3094393..3094536 + 144 WP_162306738.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

mRNA interferase PemK-like

(2-103)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9566.99 Da        Isoelectric Point: 5.6194

>T136589 WP_147665270.1 NZ_CP042905:3089755-3090000 [Candidatus Prometheoarchaeum syntrophicum]
IKTKLIQIGNSKGIRIPKHILERLNLQNKIELIIDDKINQIHIKSIETPRKNWEDAFQKMHENRDDDLLIDDGIDLDALD
W

Download         Length: 246 bp

>T136589 NZ_CP042905:3089755-3090000 [Candidatus Prometheoarchaeum syntrophicum]
ATAAAAACAAAACTTATTCAAATTGGAAATTCTAAAGGAATCCGAATACCGAAACACATTTTGGAACGTCTGAACCTACA
AAATAAAATAGAACTTATAATTGATGATAAAATCAATCAAATTCACATTAAATCAATCGAGACTCCCCGAAAGAATTGGG
AAGATGCTTTTCAAAAAATGCATGAAAACCGAGATGATGATCTTTTAATTGATGATGGAATTGACTTAGATGCTTTGGAT
TGGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12088.46 Da        Isoelectric Point: 10.5859

>AT136589 WP_162306862.1 NZ_CP042905:3090022-3090339 [Candidatus Prometheoarchaeum syntrophicum]
IKQYSVYLLNLDPTVGHEIKKTRPCVVISPDEMNKHLKTIIIAPMTTKSQDYPTRIKIKFAGKMGWLVVDQIRTVDRIRF
VKKMGTISSSSIKELKKKVQEMLVD

Download         Length: 318 bp

>AT136589 NZ_CP042905:3090022-3090339 [Candidatus Prometheoarchaeum syntrophicum]
ATCAAACAATATTCTGTGTATTTATTGAATTTAGATCCTACAGTAGGACATGAGATAAAAAAAACTAGACCATGTGTGGT
AATATCTCCAGATGAGATGAATAAACATTTAAAAACAATTATTATTGCTCCTATGACTACTAAATCTCAAGACTATCCAA
CCAGAATCAAAATAAAATTTGCAGGAAAAATGGGATGGTTAGTTGTCGATCAAATCCGTACAGTTGATAGAATACGATTT
GTTAAAAAGATGGGAACAATTAGTTCAAGTTCTATTAAAGAGCTAAAAAAAAAGGTTCAAGAAATGTTAGTAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References