Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2957786..2958630 Replicon chromosome
Accession NZ_CP042903
Organism Escherichia coli strain CFSAN061761

Toxin (Protein)


Gene name yeeV Uniprot ID B1LJY4
Locus tag CA899_RS14305 Protein ID WP_000854686.1
Coordinates 2957786..2958169 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0J1S3
Locus tag CA899_RS14310 Protein ID WP_001285602.1
Coordinates 2958250..2958630 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA899_RS14265 (2952886) 2952886..2953437 - 552 WP_116291661.1 hypothetical protein -
CA899_RS14270 (2953903) 2953903..2954208 + 306 WP_000849924.1 hypothetical protein -
CA899_RS14275 (2954292) 2954292..2954696 - 405 Protein_2804 zinc-binding phosphatase -
CA899_RS14280 (2954751) 2954751..2955689 - 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
CA899_RS14290 (2956160) 2956160..2957002 - 843 WP_001431817.1 DUF4942 domain-containing protein -
CA899_RS14295 (2957087) 2957087..2957284 - 198 WP_000839253.1 DUF957 domain-containing protein -
CA899_RS14300 (2957301) 2957301..2957789 - 489 WP_001054233.1 DUF5983 family protein -
CA899_RS14305 (2957786) 2957786..2958169 - 384 WP_000854686.1 TA system toxin CbtA family protein Toxin
CA899_RS14310 (2958250) 2958250..2958630 - 381 WP_001285602.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CA899_RS14315 (2958641) 2958641..2959324 - 684 WP_000086768.1 hypothetical protein -
CA899_RS14320 (2959343) 2959343..2959564 - 222 WP_029402821.1 DUF987 domain-containing protein -
CA899_RS14325 (2959633) 2959633..2960109 - 477 WP_001186773.1 RadC family protein -
CA899_RS14330 (2960125) 2960125..2960610 - 486 WP_000214405.1 antirestriction protein -
CA899_RS14335 (2960701) 2960701..2961522 - 822 WP_038349018.1 DUF932 domain-containing protein -
CA899_RS14340 (2961623) 2961623..2961855 - 233 Protein_2816 DUF905 domain-containing protein -
CA899_RS14345 (2961934) 2961934..2962389 - 456 WP_001504120.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-113)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14272.28 Da        Isoelectric Point: 6.8614

>T136581 WP_000854686.1 NZ_CP042903:c2958169-2957786 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Download         Length: 384 bp

>T136581 NZ_CP042903:c2958169-2957786 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13938.69 Da        Isoelectric Point: 5.0823

>AT136581 WP_001285602.1 NZ_CP042903:c2958630-2958250 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT136581 NZ_CP056146:c128993-128706 [Klebsiella variicola]
ATGCTATACAAGAGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAATGGCCTGTCAGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGCGGAGTTCATCGATATGCTTGATGCACCCGTTACAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References