136558

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3577140..3577758 Replicon chromosome
Accession NZ_CP042901
Organism Escherichia coli strain CFSAN061762

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CA898_RS17315 Protein ID WP_001291435.1
Coordinates 3577540..3577758 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag CA898_RS17310 Protein ID WP_000344800.1
Coordinates 3577140..3577514 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA898_RS17300 (3572229) 3572229..3573422 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CA898_RS17305 (3573445) 3573445..3576594 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
CA898_RS17310 (3577140) 3577140..3577514 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
CA898_RS17315 (3577540) 3577540..3577758 + 219 WP_001291435.1 HHA domain-containing protein Toxin
CA898_RS17320 (3577930) 3577930..3578481 + 552 WP_000102564.1 maltose O-acetyltransferase -
CA898_RS17325 (3578597) 3578597..3579067 + 471 WP_000136192.1 YlaC family protein -
CA898_RS17330 (3579231) 3579231..3580781 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
CA898_RS17335 (3580823) 3580823..3581176 - 354 WP_000878140.1 DUF1428 domain-containing protein -
CA898_RS17345 (3581555) 3581555..3581866 + 312 WP_000409911.1 MGMT family protein -
CA898_RS17350 (3581897) 3581897..3582469 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T136558 WP_001291435.1 NZ_CP042901:3577540-3577758 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T136558 NZ_CP042901:3577540-3577758 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT136558 WP_000344800.1 NZ_CP042901:3577140-3577514 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT136558 NZ_CP042901:3577140-3577514 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References