Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1944621..1945453 | Replicon | chromosome |
| Accession | NZ_CP042899 | ||
| Organism | Escherichia coli strain CFSAN061763 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1L4HFA4 |
| Locus tag | CA897_RS09285 | Protein ID | WP_032163901.1 |
| Coordinates | 1944621..1944995 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | CA897_RS09290 | Protein ID | WP_001295723.1 |
| Coordinates | 1945085..1945453 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CA897_RS09245 (1940017) | 1940017..1941183 | + | 1167 | WP_042031746.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| CA897_RS09250 (1941302) | 1941302..1941775 | + | 474 | WP_001105415.1 | DNA gyrase inhibitor SbmC | - |
| CA897_RS09255 (1941973) | 1941973..1943031 | + | 1059 | WP_001200891.1 | FUSC family protein | - |
| CA897_RS09260 (1943203) | 1943203..1943532 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| CA897_RS09265 (1943633) | 1943633..1943767 | - | 135 | WP_001297944.1 | EutP/PduV family microcompartment system protein | - |
| CA897_RS09270 (1943887) | 1943887..1944015 | + | 129 | Protein_1821 | transposase domain-containing protein | - |
| CA897_RS09275 (1944304) | 1944304..1944384 | - | 81 | Protein_1822 | hypothetical protein | - |
| CA897_RS09280 (1944430) | 1944430..1944624 | - | 195 | WP_000988600.1 | DUF5983 family protein | - |
| CA897_RS09285 (1944621) | 1944621..1944995 | - | 375 | WP_032163901.1 | TA system toxin CbtA family protein | Toxin |
| CA897_RS09290 (1945085) | 1945085..1945453 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CA897_RS09295 (1945616) | 1945616..1945837 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| CA897_RS09300 (1945900) | 1945900..1946376 | - | 477 | WP_001186726.1 | RadC family protein | - |
| CA897_RS09305 (1946392) | 1946392..1946877 | - | 486 | WP_000849582.1 | antirestriction protein | - |
| CA897_RS09310 (1946932) | 1946932..1947750 | - | 819 | WP_040061766.1 | DUF932 domain-containing protein | - |
| CA897_RS09315 (1947850) | 1947850..1948083 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| CA897_RS09320 (1948162) | 1948162..1948617 | - | 456 | WP_000581504.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13919.89 Da Isoelectric Point: 7.7760
>T136519 WP_032163901.1 NZ_CP042899:c1944995-1944621 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T136519 NZ_CP042899:c1944995-1944621 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT136519 WP_001295723.1 NZ_CP042899:c1945453-1945085 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT136519 NZ_CP042899:c1945453-1945085 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1L4HFA4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S1NM52 |