Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 918887..919541 Replicon chromosome
Accession NZ_CP042899
Organism Escherichia coli strain CFSAN061763

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag CA897_RS04410 Protein ID WP_000244777.1
Coordinates 919134..919541 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CA897_RS04405 Protein ID WP_000354046.1
Coordinates 918887..919153 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA897_RS04380 (914056) 914056..914799 + 744 WP_000951948.1 SDR family oxidoreductase -
CA897_RS04385 (914856) 914856..916289 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
CA897_RS04390 (916334) 916334..916645 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
CA897_RS04395 (916809) 916809..917468 + 660 WP_116319264.1 hemolysin III family protein -
CA897_RS04400 (917664) 917664..918644 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
CA897_RS04405 (918887) 918887..919153 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CA897_RS04410 (919134) 919134..919541 + 408 WP_000244777.1 protein YgfX Toxin
CA897_RS04415 (919581) 919581..920102 - 522 WP_001055874.1 flavodoxin FldB -
CA897_RS04420 (920214) 920214..921110 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
CA897_RS04425 (921135) 921135..921845 + 711 WP_000715216.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CA897_RS04430 (921851) 921851..923584 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T136515 WP_000244777.1 NZ_CP042899:919134-919541 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T136515 NZ_CP042899:919134-919541 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT136515 WP_000354046.1 NZ_CP042899:918887-919153 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT136515 NZ_CP056118:c819710-819444 [Enterobacter sp. DSM 30060]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References