Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 826909..827741 | Replicon | chromosome |
Accession | NZ_CP042899 | ||
Organism | Escherichia coli strain CFSAN061763 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A3P5UBZ5 |
Locus tag | CA897_RS03930 | Protein ID | WP_001094454.1 |
Coordinates | 826909..827283 (-) | Length | 125 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A3G8RJV8 |
Locus tag | CA897_RS03935 | Protein ID | WP_001320394.1 |
Coordinates | 827373..827741 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CA897_RS03900 (822023) | 822023..823171 | - | 1149 | WP_000905931.1 | capsule polysaccharide export inner-membrane protein KpsE | - |
CA897_RS03905 (823243) | 823243..824226 | - | 984 | WP_024181915.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
CA897_RS03910 (825036) | 825036..825206 | - | 171 | Protein_770 | IS110 family transposase | - |
CA897_RS03915 (825549) | 825549..826118 | - | 570 | WP_001290250.1 | DUF4942 domain-containing protein | - |
CA897_RS03920 (826215) | 826215..826412 | - | 198 | WP_000839276.1 | DUF957 domain-containing protein | - |
CA897_RS03925 (826424) | 826424..826912 | - | 489 | WP_000777545.1 | DUF5983 family protein | - |
CA897_RS03930 (826909) | 826909..827283 | - | 375 | WP_001094454.1 | TA system toxin CbtA family protein | Toxin |
CA897_RS03935 (827373) | 827373..827741 | - | 369 | WP_001320394.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
CA897_RS03940 (827791) | 827791..828434 | - | 644 | Protein_776 | antitoxin of toxin-antitoxin stability system | - |
CA897_RS03945 (828453) | 828453..828674 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
CA897_RS03950 (828737) | 828737..829213 | - | 477 | WP_001347688.1 | RadC family protein | - |
CA897_RS03955 (829229) | 829229..829714 | - | 486 | WP_029701480.1 | antirestriction protein | - |
CA897_RS03960 (829769) | 829769..830587 | - | 819 | WP_001234642.1 | DUF932 domain-containing protein | - |
CA897_RS03965 (830687) | 830687..830920 | - | 234 | WP_001119719.1 | DUF905 family protein | - |
CA897_RS03970 (830999) | 830999..831454 | - | 456 | WP_000581493.1 | IrmA family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14059.10 Da Isoelectric Point: 9.2447
>T136514 WP_001094454.1 NZ_CP042899:c827283-826909 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T136514 NZ_CP042899:c827283-826909 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13623.22 Da Isoelectric Point: 6.4783
>AT136514 WP_001320394.1 NZ_CP042899:c827741-827373 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ
Download Length: 369 bp
>AT136514 NZ_CP042899:c827741-827373 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3P5UBZ5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3G8RJV8 |