Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 826909..827741 Replicon chromosome
Accession NZ_CP042899
Organism Escherichia coli strain CFSAN061763

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag CA897_RS03930 Protein ID WP_001094454.1
Coordinates 826909..827283 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag CA897_RS03935 Protein ID WP_001320394.1
Coordinates 827373..827741 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA897_RS03900 (822023) 822023..823171 - 1149 WP_000905931.1 capsule polysaccharide export inner-membrane protein KpsE -
CA897_RS03905 (823243) 823243..824226 - 984 WP_024181915.1 KpsF/GutQ family sugar-phosphate isomerase -
CA897_RS03910 (825036) 825036..825206 - 171 Protein_770 IS110 family transposase -
CA897_RS03915 (825549) 825549..826118 - 570 WP_001290250.1 DUF4942 domain-containing protein -
CA897_RS03920 (826215) 826215..826412 - 198 WP_000839276.1 DUF957 domain-containing protein -
CA897_RS03925 (826424) 826424..826912 - 489 WP_000777545.1 DUF5983 family protein -
CA897_RS03930 (826909) 826909..827283 - 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
CA897_RS03935 (827373) 827373..827741 - 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CA897_RS03940 (827791) 827791..828434 - 644 Protein_776 antitoxin of toxin-antitoxin stability system -
CA897_RS03945 (828453) 828453..828674 - 222 WP_000692300.1 DUF987 domain-containing protein -
CA897_RS03950 (828737) 828737..829213 - 477 WP_001347688.1 RadC family protein -
CA897_RS03955 (829229) 829229..829714 - 486 WP_029701480.1 antirestriction protein -
CA897_RS03960 (829769) 829769..830587 - 819 WP_001234642.1 DUF932 domain-containing protein -
CA897_RS03965 (830687) 830687..830920 - 234 WP_001119719.1 DUF905 family protein -
CA897_RS03970 (830999) 830999..831454 - 456 WP_000581493.1 IrmA family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T136514 WP_001094454.1 NZ_CP042899:c827283-826909 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T136514 NZ_CP042899:c827283-826909 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT136514 WP_001320394.1 NZ_CP042899:c827741-827373 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT136514 NZ_CP042899:c827741-827373 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5


Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References