Detailed information of TA system TA136498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3112561..3113266
• Replicon: chromosome
• Accession: NZ_CP042896
• Organism: Escherichia coli strain CFSAN061771

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S1F406
• Locus tag: CA902_RS14785
• Protein ID: WP_000539521.1
• Coordinates: 3112561..3112947 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CA902_RS14790
• Protein ID: WP_001280945.1
• Coordinates: 3112937..3113266 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA902_RS14765 (3108565)	3108565..3109191	+	627	WP_001295292.1	glutathione S-transferase GstB	-
CA902_RS14770 (3109188)	3109188..3110303	-	1116	WP_000554964.1	aldose sugar dehydrogenase YliI	-
CA902_RS14775 (3110414)	3110414..3110797	-	384	WP_000497137.1	biofilm formation regulator BssR	-
CA902_RS14780 (3111010)	3111010..3112335	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
CA902_RS14785 (3112561)	3112561..3112947	+	387	WP_000539521.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CA902_RS14790 (3112937)	3112937..3113266	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
CA902_RS14795 (3113336)	3113336..3114664	-	1329	WP_116350167.1	GGDEF domain-containing protein	-
CA902_RS14800 (3114672)	3114672..3117020	-	2349	WP_022645413.1	EAL domain-containing protein	-
CA902_RS14805 (3117197)	3117197..3118108	-	912	WP_001236044.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.45 Da
• Isoelectric Point: 9.9296

>T136498 WP_000539521.1 NZ_CP042896:3112561-3112947 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T136498 NZ_CP042896:3112561-3112947 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGTAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT136498 WP_001280945.1 NZ_CP042896:3112937-3113266 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT136498 NZ_CP042896:3112937-3113266 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A829GCT6