Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2455430..2456068 Replicon chromosome
Accession NZ_CP042896
Organism Escherichia coli strain CFSAN061771

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag CA902_RS11605 Protein ID WP_000813794.1
Coordinates 2455892..2456068 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CA902_RS11600 Protein ID WP_001270286.1
Coordinates 2455430..2455846 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA902_RS11580 (2450582) 2450582..2451523 - 942 WP_088129997.1 ABC transporter permease -
CA902_RS11585 (2451524) 2451524..2452537 - 1014 WP_022645666.1 ABC transporter ATP-binding protein -
CA902_RS11590 (2452555) 2452555..2453700 - 1146 WP_000047466.1 ABC transporter substrate-binding protein -
CA902_RS11595 (2453945) 2453945..2455351 - 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
CA902_RS11600 (2455430) 2455430..2455846 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
CA902_RS11605 (2455892) 2455892..2456068 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
CA902_RS11610 (2456290) 2456290..2456520 + 231 WP_000491567.1 DUF2554 family protein -
CA902_RS11615 (2456612) 2456612..2458573 - 1962 WP_023909195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
CA902_RS11620 (2458646) 2458646..2459182 - 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
CA902_RS11625 (2459274) 2459274..2460446 + 1173 WP_022645663.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T136496 WP_000813794.1 NZ_CP042896:c2456068-2455892 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T136496 NZ_CP042896:c2456068-2455892 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTAAAACTGAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT136496 WP_001270286.1 NZ_CP042896:c2455846-2455430 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT136496 NZ_CP042896:c2455846-2455430 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAACAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References