Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 958520..959174 Replicon chromosome
Accession NZ_CP042896
Organism Escherichia coli strain CFSAN061771

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag CA902_RS04590 Protein ID WP_000244765.1
Coordinates 958767..959174 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag CA902_RS04585 Protein ID WP_000354046.1
Coordinates 958520..958786 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA902_RS04565 (954608) 954608..956041 - 1434 WP_063082439.1 6-phospho-beta-glucosidase BglA -
CA902_RS04570 (956086) 956086..956397 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
CA902_RS04575 (956561) 956561..957220 + 660 WP_000250274.1 hemolysin III family protein -
CA902_RS04580 (957297) 957297..958277 - 981 WP_049038218.1 tRNA-modifying protein YgfZ -
CA902_RS04585 (958520) 958520..958786 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
CA902_RS04590 (958767) 958767..959174 + 408 WP_000244765.1 protein YgfX Toxin
CA902_RS04595 (959214) 959214..959735 - 522 WP_001055874.1 flavodoxin FldB -
CA902_RS04600 (959847) 959847..960743 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
CA902_RS04605 (960768) 960768..961478 + 711 WP_088845923.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CA902_RS04610 (961484) 961484..963217 + 1734 WP_000813190.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T136485 WP_000244765.1 NZ_CP042896:958767-959174 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T136485 NZ_CP042896:958767-959174 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT136485 WP_000354046.1 NZ_CP042896:958520-958786 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT136485 NZ_CP056087:2085143-2085988 [Pseudomonas argentinensis]
ATGCCTACCGGCGAGCGCATCCGCTTTTGGGAAAGCCCCGCACTGGCCGGTGTCGAACTGCTGCAGGCGCGCTATATCAA
GCAGCGCTTCACCCCCCACGTGCACGAAGGCTTCGTGTTCACCGTGATCGAGGGCGGCGCCCAGCGCTTTCGCCATCGTG
GCGCCGACCACCTGGCGCCGATTGGCAGCATGGTGTTGATCAACCCCGATGAAGTGCACACCGGCTCGGCCGCCCACGAG
CAGGGCTGGTTCTATCGAGCGTTCTACCCGGCCCCGGCACAGGTCAGCGGTGTGCTCGACGAGCTCGGGCTGGCGCAACG
CGGCTTGCCGTCGTTCGCCGCCAGCGTGCTGCAGGATGTGCAGTTGCACCAGGCGTTCGGCCAGCTGCATCGCTTGCTCG
ACAGCGACGCCAGCGTGCTGCAACAGCAGACCGCCTGGCGCGAGACGCTGCTGCTGCTGCTGTTCCAGCGCCATGCCGGC
GTCAGGCAGGCGCCAACGCCTGGCCAGGAGCCACGGGCGGTAAGCCTGGCCAAGGAGCTCTTGGCCGCGCGCCTGGGCGA
GCCACCGACACTGGAAGCATTGGCGGCTGCGGTGAACCTCTCGCCGTTTCACTTCGCCCGGGTATTTCGCCGCGCCACCG
GCCTGCCGCCCCATGCCTGGCTGCAGCAACGCCGCCTGGAGCGGGCACGGGCGCTGTTGCGTAATGGCTGCGCGCCGCTG
AGCGTGGCGCTGCAGCTGGGCTTTGCCGACCAGAGCCACCTGACGCGGCAGTTCAAGCAGGTGTATGGCGTGGGCCCCGG
CGAGTACCGCAAGGCCTGCCATCGCAGCCCCGTAGCCTGTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References