Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2388595..2389233 Replicon chromosome
Accession NZ_CP042893
Organism Escherichia coli strain CFSAN061772

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag CA901_RS11540 Protein ID WP_000813794.1
Coordinates 2389057..2389233 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CA901_RS11535 Protein ID WP_001270286.1
Coordinates 2388595..2389011 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA901_RS11515 (2383747) 2383747..2384688 - 942 WP_116439147.1 ABC transporter permease -
CA901_RS11520 (2384689) 2384689..2385702 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
CA901_RS11525 (2385720) 2385720..2386865 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
CA901_RS11530 (2387110) 2387110..2388516 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
CA901_RS11535 (2388595) 2388595..2389011 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
CA901_RS11540 (2389057) 2389057..2389233 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
CA901_RS11545 (2389455) 2389455..2389685 + 231 WP_000494244.1 YncJ family protein -
CA901_RS11550 (2389777) 2389777..2391738 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
CA901_RS11555 (2391811) 2391811..2392347 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
CA901_RS11560 (2392439) 2392439..2393614 + 1176 WP_259393600.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T136472 WP_000813794.1 NZ_CP042893:c2389233-2389057 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T136472 NZ_CP056080:c1721710-1721456 [Rothia nasimurium]
ATGAAAATCGTGTGGGATGAAAACGCCTGGGAAGACTACCTCTGGTGGCAGCAACAGGACCGCAAAGTCCTCAAACGCAT
TAACACTCTGATTAAAGATATTGCCCGCAACGGGCACGAGGGCATCGGCAAACCCGAGGCCCTTAAACACGACTGGTCAG
GGTTCTGGTCGCGGCGGATTACAGACGAACACAGACTCATTTATGCGATAACAGATACGGCAATATTGATTGCCGCCTGC
AGATACCACTACTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT136472 WP_001270286.1 NZ_CP042893:c2389011-2388595 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT136472 NZ_CP056080:c1721968-1721714 [Rothia nasimurium]
ATGAAAACAATGACCTATTCAGAATCTCGGGCTCGTTACGCAGAGGTCATGGACTCTGTTATCAACGACCGCGAAGAAGT
CGTCATCACTAGAGTGGGGCACGACCCCGTCGTCATGCTATCGCTCGAAGACTATGAGTCCCTCAAAGAAGCCGCCTACC
TCATGCGCTCCCCCCGGAACGCTCGTCGAATCTCTGACTCAATCGCGCGACTGAAAGCTGGTCTGGGGGAAAAGCACCAG
CTGATCGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References