Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 700870..701688 | Replicon | chromosome |
| Accession | NZ_CP042892 | ||
| Organism | Escherichia coli O10:H32 strain NMBU-W12E19 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0E0Y102 |
| Locus tag | FVP48_RS06030 | Protein ID | WP_000771609.1 |
| Coordinates | 700870..701244 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0E0Y470 |
| Locus tag | FVP48_RS06035 | Protein ID | WP_001285568.1 |
| Coordinates | 701335..701688 (-) | Length | 118 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FVP48_RS05990 | 695873..696364 | - | 492 | WP_001300785.1 | DUF1097 domain-containing protein | - |
| FVP48_RS05995 | 696466..697020 | - | 555 | WP_001001921.1 | molecular chaperone YcdY | - |
| FVP48_RS06000 | 697044..697781 | - | 738 | WP_000283667.1 | zinc-binding phosphatase | - |
| FVP48_RS06005 | 697836..698774 | - | 939 | WP_118020180.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| FVP48_RS06015 | 699246..700088 | - | 843 | WP_001423379.1 | DUF4942 domain-containing protein | - |
| FVP48_RS06020 | 700173..700370 | - | 198 | WP_001391464.1 | DUF957 domain-containing protein | - |
| FVP48_RS06025 | 700382..700873 | - | 492 | WP_000976860.1 | hypothetical protein | - |
| FVP48_RS06030 | 700870..701244 | - | 375 | WP_000771609.1 | TA system toxin CbtA family protein | Toxin |
| FVP48_RS06035 | 701335..701688 | - | 354 | WP_001285568.1 | type IV toxin-antitoxin system toxin CbtA | Antitoxin |
| FVP48_RS06040 | 701764..701985 | - | 222 | WP_000692360.1 | DUF987 domain-containing protein | - |
| FVP48_RS06045 | 702048..702524 | - | 477 | WP_001423376.1 | RadC family protein | - |
| FVP48_RS06050 | 702540..703013 | - | 474 | WP_021554325.1 | antirestriction protein | - |
| FVP48_RS06055 | 703107..703352 | - | 246 | WP_001164966.1 | hypothetical protein | - |
| FVP48_RS06060 | 703352..704173 | - | 822 | WP_173002266.1 | DUF945 domain-containing protein | - |
| FVP48_RS06065 | 704394..704804 | - | 411 | WP_000846716.1 | hypothetical protein | - |
| FVP48_RS06070 | 704820..705503 | - | 684 | WP_000775510.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14006.09 Da Isoelectric Point: 7.2652
>T136437 WP_000771609.1 NZ_CP042892:c701244-700870 [Escherichia coli O10:H32]
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
MKLLPDTHVREASCCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK
Download Length: 375 bp
>T136437 NZ_CP056073:3087391-3087777 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA
ATGGGTGTGTATAAGGCAAGGCGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAAGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGGTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCAGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTCTTGATTGAGGTGAAAAATGAGCGATAA
Antitoxin
Download Length: 118 a.a. Molecular weight: 13064.82 Da Isoelectric Point: 5.9541
>AT136437 WP_001285568.1 NZ_CP042892:c701688-701335 [Escherichia coli O10:H32]
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
VSDTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPR
HQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
Download Length: 354 bp
>AT136437 NZ_CP042892:c701688-701335 [Escherichia coli O10:H32]
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
GTGTCAGACACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACGCTATATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y102 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y470 |