Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4015377..4015996 Replicon chromosome
Accession NZ_CP042882
Organism Klebsiella pneumoniae strain NMBU-W07E18

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FVP31_RS19620 Protein ID WP_002892050.1
Coordinates 4015778..4015996 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FVP31_RS19615 Protein ID WP_002892066.1
Coordinates 4015377..4015751 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVP31_RS19605 4010529..4011722 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FVP31_RS19610 4011745..4014891 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
FVP31_RS19615 4015377..4015751 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FVP31_RS19620 4015778..4015996 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FVP31_RS19625 4016155..4016721 + 567 WP_002892030.1 maltose O-acetyltransferase -
FVP31_RS19630 4016693..4016833 - 141 WP_032410934.1 hypothetical protein -
FVP31_RS19635 4016854..4017324 + 471 WP_040187972.1 YlaC family protein -
FVP31_RS19640 4017299..4017778 - 480 WP_086556125.1 GntR family transcriptional regulator -
FVP31_RS19645 4017879..4018577 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
FVP31_RS19650 4018574..4018714 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FVP31_RS19655 4018714..4018977 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -
FVP31_RS19660 4019093..4020163 - 1071 WP_002892007.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T136410 WP_002892050.1 NZ_CP042882:4015778-4015996 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T136410 NZ_CP042882:4015778-4015996 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT136410 WP_002892066.1 NZ_CP042882:4015377-4015751 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT136410 NZ_CP056036:2647405-2647671 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGTATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References