Detailed information of TA system TA136400

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 803996..804653
• Replicon: chromosome
• Accession: NZ_CP042882
• Organism: Klebsiella pneumoniae strain NMBU-W07E18

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FVP31_RS03985
• Protein ID: WP_040245400.1
• Coordinates: 804243..804653 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: FVP31_RS03980
• Protein ID: WP_002916312.1
• Coordinates: 803996..804262 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVP31_RS03955	799152..800585	-	1434	WP_099761700.1	6-phospho-beta-glucosidase BglA	-
FVP31_RS03960	800704..801432	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
FVP31_RS03965	801482..801793	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
FVP31_RS03970	801957..802616	+	660	WP_002916317.1	hemolysin III family protein	-
FVP31_RS03975	802767..803750	-	984	WP_099761701.1	tRNA-modifying protein YgfZ	-
FVP31_RS03980	803996..804262	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
FVP31_RS03985	804243..804653	+	411	WP_040245400.1	protein YgfX	Toxin
FVP31_RS03990	804660..805181	-	522	WP_002916308.1	flavodoxin FldB	-
FVP31_RS03995	805282..806178	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
FVP31_RS04000	806201..806914	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
FVP31_RS04005	806920..808653	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T136400 WP_040245400.1 NZ_CP042882:804243-804653 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T136400 NZ_CP042882:804243-804653 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATAGCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT136400 WP_002916312.1 NZ_CP042882:803996-804262 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT136400 NZ_CP056034:c2871391-2871164 [Erwinia amylovora]
GTGCGGCTGGATGACAAACTGAAAAGCAAAGCCTGTGCAGTTCTGGATGAACTGGATGTATCGCCAACGGAGGCGGTCCG
GCTGTTGTTCCAGTATATAGCGGAAAATGAGCGCCTACCGCTGAAAGCGCTGACGGTAAGTGATGAAAAAGACGCGCTGC
TGAAAACGGTTCGCGAAAGGCTGGCATCGCTACAGAAGGGAATAAAGGTAACGCTGGATAAGCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41