Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 915989..916823 Replicon chromosome
Accession NZ_CP042878
Organism Escherichia coli strain NMBU_W05E18

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag FVA71_RS04360 Protein ID WP_000854689.1
Coordinates 915989..916366 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0IVP8
Locus tag FVA71_RS04365 Protein ID WP_001285599.1
Coordinates 916443..916823 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA71_RS04330 912383..912538 - 156 WP_000729638.1 hypothetical protein -
FVA71_RS04335 912970..913903 - 934 Protein_851 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
FVA71_RS04340 913896..914291 - 396 WP_000208382.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
FVA71_RS04345 914360..915205 - 846 WP_001530851.1 DUF4942 domain-containing protein -
FVA71_RS04350 915290..915487 - 198 WP_000839250.1 DUF957 domain-containing protein -
FVA71_RS04355 915504..915992 - 489 WP_000761698.1 hypothetical protein -
FVA71_RS04360 915989..916366 - 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
FVA71_RS04365 916443..916823 - 381 WP_001285599.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
FVA71_RS04370 916873..917517 - 645 WP_000086757.1 hypothetical protein -
FVA71_RS04375 917536..917757 - 222 WP_000692315.1 DUF987 domain-containing protein -
FVA71_RS04380 917822..918298 - 477 WP_001186727.1 RadC family protein -
FVA71_RS04385 918314..918787 - 474 WP_001538139.1 antirestriction protein -
FVA71_RS04390 919051..919872 - 822 WP_173009496.1 DUF945 domain-containing protein -
FVA71_RS04395 919973..920182 - 210 Protein_863 DUF905 family protein -
FVA71_RS04400 920283..920738 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF 894005..917517 23512
- flank IS/Tn - - 912383..912538 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T136355 WP_000854689.1 NZ_CP042878:c916366-915989 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T136355 NZ_CP042878:c916366-915989 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13984.78 Da        Isoelectric Point: 5.0823

>AT136355 WP_001285599.1 NZ_CP042878:c916823-916443 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT136355 NZ_CP042878:c916823-916443 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGTTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References