Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4116373..4116968 Replicon chromosome
Accession NZ_CP042867
Organism Escherichia coli strain ATCC BAA-196

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag BAA196FS_RS20135 Protein ID WP_000239577.1
Coordinates 4116373..4116723 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag BAA196FS_RS20140 Protein ID WP_001223208.1
Coordinates 4116717..4116968 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAA196FS_RS20115 4111819..4112841 - 1023 WP_001313531.1 ABC transporter permease -
BAA196FS_RS20120 4112855..4114357 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
BAA196FS_RS20125 4114497..4115453 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
BAA196FS_RS20130 4115763..4116293 + 531 WP_000055075.1 inorganic diphosphatase -
BAA196FS_RS20135 4116373..4116723 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
BAA196FS_RS20140 4116717..4116968 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
BAA196FS_RS20145 4117180..4117521 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
BAA196FS_RS20150 4117524..4121303 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T136347 WP_000239577.1 NZ_CP042867:c4116723-4116373 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T136347 NZ_CP055599:c2517760-2517653 [Escherichia fergusonii]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT136347 WP_001223208.1 NZ_CP042867:c4116968-4116717 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT136347 NZ_CP042867:c4116968-4116717 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References