Detailed information of TA system TA136346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4030163..4030977
• Replicon: chromosome
• Accession: NZ_CP042867
• Organism: Escherichia coli strain ATCC BAA-196

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: BAA196FS_RS19705
• Protein ID: WP_001054376.1
• Coordinates: 4030163..4030420 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: BAA196FS_RS19710
• Protein ID: WP_001309181.1
• Coordinates: 4030432..4030977 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAA196FS_RS19685	4025451..4026557	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
BAA196FS_RS19690	4026622..4027602	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
BAA196FS_RS19695	4028185..4029171	-	987	WP_001323209.1	hypothetical protein	-
BAA196FS_RS19700	4029541..4029786	+	246	Protein_3822	GNAT family N-acetyltransferase	-
BAA196FS_RS19705	4030163..4030420	+	258	WP_001054376.1	hypothetical protein	Toxin
BAA196FS_RS19710	4030432..4030977	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
BAA196FS_RS19715	4031033..4031779	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
BAA196FS_RS19720	4031948..4032166	+	219	Protein_3826	hypothetical protein	-
BAA196FS_RS19725	4032565..4033686	+	1122	WP_000010829.1	M42 family metallopeptidase	-
BAA196FS_RS19730	4033683..4033961	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
BAA196FS_RS19735	4033973..4035286	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	4019949..4039201	19252

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T136346 WP_001054376.1 NZ_CP042867:4030163-4030420 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T136346 NZ_CP042867:4030163-4030420 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT136346 WP_001309181.1 NZ_CP042867:4030432-4030977 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT136346 NZ_CP042867:4030432-4030977 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8