136341

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3456416..3457034 Replicon chromosome
Accession NZ_CP042867
Organism Escherichia coli strain ATCC BAA-196

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag BAA196FS_RS16985 Protein ID WP_001291435.1
Coordinates 3456816..3457034 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag BAA196FS_RS16980 Protein ID WP_000344800.1
Coordinates 3456416..3456790 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAA196FS_RS16970 3451505..3452698 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
BAA196FS_RS16975 3452721..3455870 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
BAA196FS_RS16980 3456416..3456790 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
BAA196FS_RS16985 3456816..3457034 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
BAA196FS_RS16990 3457206..3457757 + 552 WP_000102564.1 maltose O-acetyltransferase -
BAA196FS_RS16995 3457873..3458343 + 471 WP_000136192.1 YlaC family protein -
BAA196FS_RS17000 3458507..3460057 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
BAA196FS_RS17005 3460099..3460452 - 354 WP_000878140.1 DUF1428 domain-containing protein -
BAA196FS_RS17015 3460831..3461142 + 312 WP_000409911.1 MGMT family protein -
BAA196FS_RS17020 3461173..3461745 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T136341 WP_001291435.1 NZ_CP042867:3456816-3457034 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T136341 NZ_CP042867:3456816-3457034 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT136341 WP_000344800.1 NZ_CP042867:3456416-3456790 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT136341 NZ_CP042867:3456416-3456790 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References