Detailed information of TA system TA136340

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2376944..2377582
• Replicon: chromosome
• Accession: NZ_CP042867
• Organism: Escherichia coli strain ATCC BAA-196

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S1F9G9
• Locus tag: BAA196FS_RS11545
• Protein ID: WP_000813794.1
• Coordinates: 2377406..2377582 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BAA196FS_RS11540
• Protein ID: WP_001270286.1
• Coordinates: 2376944..2377360 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAA196FS_RS11520	2372096..2373037	-	942	WP_001251304.1	ABC transporter permease	-
BAA196FS_RS11525	2373038..2374051	-	1014	WP_000220396.1	ABC transporter ATP-binding protein	-
BAA196FS_RS11530	2374069..2375214	-	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
BAA196FS_RS11535	2375459..2376865	-	1407	WP_000760626.1	PLP-dependent aminotransferase family protein	-
BAA196FS_RS11540	2376944..2377360	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
BAA196FS_RS11545	2377406..2377582	-	177	WP_000813794.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
BAA196FS_RS11550	2377804..2378034	+	231	WP_000494244.1	YncJ family protein	-
BAA196FS_RS11555	2378126..2380087	-	1962	WP_001303492.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
BAA196FS_RS11560	2380160..2380696	-	537	WP_000429155.1	DNA-binding transcriptional regulator SutR	-
BAA196FS_RS11565	2380749..2381963	+	1215	WP_001326689.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6749.83 Da
• Isoelectric Point: 11.2298

>T136340 WP_000813794.1 NZ_CP042867:c2377582-2377406 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T136340 NZ_CP042867:c2377582-2377406 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT136340 WP_001270286.1 NZ_CP042867:c2377360-2376944 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT136340 NZ_CP042867:c2377360-2376944 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• PDB: 6HPB