Detailed information of TA system TA136287

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 1393497..1394065
• Replicon: chromosome
• Accession: NZ_CP042862
• Organism: Serinicoccus profundi strain CGMCC 4.5582

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FA582_RS06340
• Protein ID: WP_010146998.1
• Coordinates: 1393739..1394065 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FA582_RS06335
• Protein ID: WP_029540555.1
• Coordinates: 1393497..1393736 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FA582_RS06320	1388910..1389233	-	324	WP_010147002.1	hypothetical protein	-
FA582_RS06325	1389436..1389873	+	438	WP_010147001.1	hypothetical protein	-
FA582_RS06330	1389925..1393362	-	3438	WP_010147000.1	SWIM zinc finger family protein	-
FA582_RS06335	1393497..1393736	+	240	WP_029540555.1	DUF2191 domain-containing protein	Antitoxin
FA582_RS06340	1393739..1394065	+	327	WP_010146998.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FA582_RS06345	1394191..1394382	+	192	WP_141567532.1	hypothetical protein	-
FA582_RS06350	1394731..1395159	+	429	WP_141567531.1	hypothetical protein	-
FA582_RS16735	1395192..1396151	+	960	WP_010146995.1	HNH endonuclease	-
FA582_RS06360	1396551..1396817	+	267	WP_029540553.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
FA582_RS06365	1396814..1397212	+	399	WP_010146993.1	PIN domain-containing protein	-
FA582_RS06370	1397637..1397999	+	363	WP_158640860.1	hypothetical protein	-
FA582_RS06375	1398047..1398952	+	906	WP_029540549.1	plasmid pRiA4b ORF-3 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-103)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 11468.24 Da
• Isoelectric Point: 6.9035

>T136287 WP_010146998.1 NZ_CP042862:1393739-1394065 [Serinicoccus profundi]
MELPTRGELWWADLDDAGARPVVVVGRDAAIAGRRRALVAPCSTVVRGLPSEVRLEPGEEPVHRPCAAQLDALTDLPISV
LTRRLGRLSDAAMRRVCAALGVAADCSS

Nucleotide

• Length: 327 bp

>T136287 NZ_CP042862:1393739-1394065 [Serinicoccus profundi]
ATGGAGCTCCCGACCAGGGGTGAGCTGTGGTGGGCGGACCTCGACGACGCCGGCGCCAGGCCCGTGGTGGTCGTCGGCCG
GGACGCCGCGATCGCCGGCCGTCGGCGCGCCCTCGTGGCGCCCTGCAGCACGGTCGTCCGGGGGCTGCCGAGCGAGGTGC
GGCTGGAGCCGGGTGAGGAACCGGTCCATCGTCCCTGCGCAGCACAGCTCGACGCCCTGACGGATCTGCCGATCTCGGTG
CTGACCCGCCGGCTCGGGCGCCTGAGCGACGCAGCGATGCGGCGGGTGTGCGCCGCGCTCGGCGTCGCCGCCGACTGCTC
CTCCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8697.68 Da
• Isoelectric Point: 4.8430

>AT136287 WP_029540555.1 NZ_CP042862:1393497-1393736 [Serinicoccus profundi]
MARVRVSTTVDAELLACARKAHAGRTDASLVEEALEALLRNHRAAEVDEAYARAYRESPVEAPDEWGDLTTFLDAAARR

Nucleotide

• Length: 240 bp

>AT136287 NZ_CP042862:1393497-1393736 [Serinicoccus profundi]
ATGGCCAGGGTGAGAGTGAGTACGACGGTGGATGCAGAGTTGCTGGCGTGCGCGCGGAAGGCGCATGCGGGCAGGACGGA
TGCGTCCCTGGTGGAGGAGGCGCTGGAGGCGCTGCTGCGGAACCACCGGGCGGCCGAGGTCGACGAGGCCTACGCCCGGG
CCTACCGCGAGAGCCCGGTGGAGGCGCCCGACGAGTGGGGGGACCTGACGACCTTCCTCGACGCGGCCGCGAGGCGCTGA