Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1393497..1394065 Replicon chromosome
Accession NZ_CP042862
Organism Serinicoccus profundi strain CGMCC 4.5582

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FA582_RS06340 Protein ID WP_010146998.1
Coordinates 1393739..1394065 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FA582_RS06335 Protein ID WP_029540555.1
Coordinates 1393497..1393736 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FA582_RS06320 1388910..1389233 - 324 WP_010147002.1 hypothetical protein -
FA582_RS06325 1389436..1389873 + 438 WP_010147001.1 hypothetical protein -
FA582_RS06330 1389925..1393362 - 3438 WP_010147000.1 SWIM zinc finger family protein -
FA582_RS06335 1393497..1393736 + 240 WP_029540555.1 DUF2191 domain-containing protein Antitoxin
FA582_RS06340 1393739..1394065 + 327 WP_010146998.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FA582_RS06345 1394191..1394382 + 192 WP_141567532.1 hypothetical protein -
FA582_RS06350 1394731..1395159 + 429 WP_141567531.1 hypothetical protein -
FA582_RS16735 1395192..1396151 + 960 WP_010146995.1 HNH endonuclease -
FA582_RS06360 1396551..1396817 + 267 WP_029540553.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FA582_RS06365 1396814..1397212 + 399 WP_010146993.1 PIN domain-containing protein -
FA582_RS06370 1397637..1397999 + 363 WP_158640860.1 hypothetical protein -
FA582_RS06375 1398047..1398952 + 906 WP_029540549.1 plasmid pRiA4b ORF-3 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11468.24 Da        Isoelectric Point: 6.9035

>T136287 WP_010146998.1 NZ_CP042862:1393739-1394065 [Serinicoccus profundi]
MELPTRGELWWADLDDAGARPVVVVGRDAAIAGRRRALVAPCSTVVRGLPSEVRLEPGEEPVHRPCAAQLDALTDLPISV
LTRRLGRLSDAAMRRVCAALGVAADCSS

Download         Length: 327 bp

>T136287 NZ_CP042862:1393739-1394065 [Serinicoccus profundi]
ATGGAGCTCCCGACCAGGGGTGAGCTGTGGTGGGCGGACCTCGACGACGCCGGCGCCAGGCCCGTGGTGGTCGTCGGCCG
GGACGCCGCGATCGCCGGCCGTCGGCGCGCCCTCGTGGCGCCCTGCAGCACGGTCGTCCGGGGGCTGCCGAGCGAGGTGC
GGCTGGAGCCGGGTGAGGAACCGGTCCATCGTCCCTGCGCAGCACAGCTCGACGCCCTGACGGATCTGCCGATCTCGGTG
CTGACCCGCCGGCTCGGGCGCCTGAGCGACGCAGCGATGCGGCGGGTGTGCGCCGCGCTCGGCGTCGCCGCCGACTGCTC
CTCCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8697.68 Da        Isoelectric Point: 4.8430

>AT136287 WP_029540555.1 NZ_CP042862:1393497-1393736 [Serinicoccus profundi]
MARVRVSTTVDAELLACARKAHAGRTDASLVEEALEALLRNHRAAEVDEAYARAYRESPVEAPDEWGDLTTFLDAAARR

Download         Length: 240 bp

>AT136287 NZ_CP042862:1393497-1393736 [Serinicoccus profundi]
ATGGCCAGGGTGAGAGTGAGTACGACGGTGGATGCAGAGTTGCTGGCGTGCGCGCGGAAGGCGCATGCGGGCAGGACGGA
TGCGTCCCTGGTGGAGGAGGCGCTGGAGGCGCTGCTGCGGAACCACCGGGCGGCCGAGGTCGACGAGGCCTACGCCCGGG
CCTACCGCGAGAGCCCGGTGGAGGCGCCCGACGAGTGGGGGGACCTGACGACCTTCCTCGACGCGGCCGCGAGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References