Detailed information of TA system TA136286

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 271187..271751
• Replicon: chromosome
• Accession: NZ_CP042862
• Organism: Serinicoccus profundi strain CGMCC 4.5582

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FA582_RS01255
• Protein ID: WP_010147404.1
• Coordinates: 271404..271751 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FA582_RS01250
• Protein ID: WP_010147405.1
• Coordinates: 271187..271417 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FA582_RS01220	267029..267268	-	240	WP_010147413.1	heavy-metal-associated domain-containing protein	-
FA582_RS01225	267348..267635	-	288	WP_193559804.1	metal-sensitive transcriptional regulator	-
FA582_RS01230	267960..268433	-	474	WP_010147411.1	SRPBCC family protein	-
FA582_RS01235	268500..269393	-	894	WP_010147410.1	macrolide 2'-phosphotransferase	-
FA582_RS01240	269548..270063	+	516	WP_010147408.1	pyridoxamine 5'-phosphate oxidase family protein	-
FA582_RS01245	270109..271053	-	945	WP_010147406.1	cold shock domain-containing protein	-
FA582_RS01250	271187..271417	+	231	WP_010147405.1	ribbon-helix-helix domain-containing protein	Antitoxin
FA582_RS01255	271404..271751	+	348	WP_010147404.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FA582_RS01260	271770..272525	-	756	WP_029540740.1	DinB family protein	-
FA582_RS01265	272561..275083	-	2523	WP_010147401.1	polynucleotide kinase-phosphatase	-
FA582_RS01270	275076..276488	-	1413	WP_010147400.1	3' terminal RNA ribose 2'-O-methyltransferase Hen1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12563.60 Da
• Isoelectric Point: 9.4854

>T136286 WP_010147404.1 NZ_CP042862:271404-271751 [Serinicoccus profundi]
MLRSEICLVDLEPARGSEANKRRPAVLVSNDRANTTAQRLGRGVVTVVPVTSNVERIFPFQVLLPMEETGLPVDSKAQAE
QVRSVAVERIGPAIGRVPSRLMAALDEALRLHLQL

Nucleotide

• Length: 348 bp

>T136286 NZ_CP042862:271404-271751 [Serinicoccus profundi]
ATGCTGCGCAGTGAGATCTGCCTGGTCGACCTCGAGCCAGCGCGCGGAAGCGAGGCGAACAAGCGCCGCCCGGCGGTGCT
CGTGAGCAACGACCGCGCCAACACCACCGCCCAGCGACTCGGTCGCGGCGTGGTCACCGTCGTGCCCGTCACCAGCAACG
TGGAGCGCATCTTCCCCTTCCAGGTGCTGCTCCCGATGGAGGAGACGGGGCTGCCCGTGGACTCCAAGGCCCAGGCTGAG
CAGGTCCGCTCGGTCGCCGTCGAACGGATCGGTCCCGCCATCGGCCGGGTCCCGTCTCGACTGATGGCTGCCCTCGATGA
GGCGTTACGGCTCCATCTGCAGCTCTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8008.74 Da
• Isoelectric Point: 3.7425

>AT136286 WP_010147405.1 NZ_CP042862:271187-271417 [Serinicoccus profundi]
MKLSVSLTAEDLAALDRYVEQAGLGSRSAAVQQAIRRLEDPLLESDYAAAWEEWVAAGDEDAWAAASADGVADAAQ

Nucleotide

• Length: 231 bp

>AT136286 NZ_CP055325:c5043306-5042515 [Klebsiella michiganensis]
ATGTCATCTAAGATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTATTCCTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTAAAGAAGCTATGTTCTGGCGTGTATTATCGTCCAG
ATGCGCAGGGCGATAGAAAGCCAACTTGGGTTGATGCCATTCAAGCATTAGATGTGCAATTGGGCGTTTCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTACAGCTGAACAAAGAGCAAGTTTGGATTTCCGTTAA
AAATAAGTCGTCCTTACCAAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGTGGAAACCATAAGCTTGAAG
TGAGTCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAACTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGACGGGATTGGGAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAGCGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGTGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATTACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA