Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4543017..4543600 Replicon chromosome
Accession NZ_CP042861
Organism Providencia sp. 1709051003

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag FVA72_RS21085 Protein ID WP_096863599.1
Coordinates 4543298..4543600 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FVA72_RS21080 Protein ID WP_004265229.1
Coordinates 4543017..4543301 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA72_RS21055 4538177..4539154 - 978 WP_004265237.1 6-phosphofructokinase -
FVA72_RS21060 4539561..4540505 - 945 WP_004265235.1 phosphatidate cytidylyltransferase -
FVA72_RS21065 4540502..4541143 - 642 WP_094961883.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
FVA72_RS21070 4541381..4542133 - 753 WP_004265231.1 M48 family metallopeptidase -
FVA72_RS21075 4542353..4542934 - 582 WP_094961882.1 HutD family protein -
FVA72_RS21080 4543017..4543301 - 285 WP_004265229.1 putative addiction module antidote protein Antitoxin
FVA72_RS21085 4543298..4543600 - 303 WP_096863599.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FVA72_RS21090 4543857..4544426 - 570 WP_110592812.1 Spy/CpxP family protein refolding chaperone -
FVA72_RS21095 4544577..4545275 + 699 WP_004265224.1 envelope stress response regulator transcription factor CpxR -
FVA72_RS21100 4545272..4546642 + 1371 WP_004265222.1 envelope stress sensor histidine kinase CpxA -
FVA72_RS21105 4547114..4548550 + 1437 WP_110592811.1 capsule assembly Wzi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11433.37 Da        Isoelectric Point: 10.0723

>T136284 WP_096863599.1 NZ_CP042861:c4543600-4543298 [Providencia sp. 1709051003]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRRLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGEL

Download         Length: 303 bp

>T136284 NZ_CP042861:c4543600-4543298 [Providencia sp. 1709051003]
ATGATCACGGTTCTAACAACGGAATGTTTTGATAGTTGGATCAAAAATCTTAGAGATATTCGAGCTAAAACTAAAATTCT
AATGAGAATTAGGCGGTTAAAAAATGGAAATTATGGTGATGTTCAACCCATTGGTGATGGCTTTTCGGAACTGAGGGTAC
ATGAAGGACAAGGGTATCGTGTTTATCTAAAGCAGAAAAACAATGTTATTGTAATTTTACTTTGTGGTGGGACAAAGGCA
ACGCAGCAGAAGGATATCCATAAAGCTAAACTTCTTTTTGGTGAAGTTGAGGGGGAACTATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10454.13 Da        Isoelectric Point: 4.5983

>AT136284 WP_004265229.1 NZ_CP042861:c4543301-4543017 [Providencia sp. 1709051003]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp

>AT136284 NZ_CP042861:c4543301-4543017 [Providencia sp. 1709051003]
ATGAATACTAAATTAAAAGAATTTGATATCGCTGAGTATTTAAACAGTGAAGAAGAAATACAAATGTATCTAAACGAAAT
TCTAGAAGAAGGTGACCCTAGTCTAGTTCTCGCTGCACTTGGTGATATTGCGAAGGCAAGAAATATGAGCCAATTAGCTA
AAGAAGTTGGAATGAGTCGTGAAGGTTTATATAAGGCGCTATCAGGACAGGGAAATCCAACATTTATGACGATTATAAAA
ATCGTTAATTCTCTCGGATTAAAGCTACAGTTTAAGAGTATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References