Detailed information of TA system TA136283

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 4269420..4270005
• Replicon: chromosome
• Accession: NZ_CP042861
• Organism: Providencia sp. 1709051003

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FVA72_RS19720
• Protein ID: WP_110591061.1
• Coordinates: 4269420..4269737 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4C3P0
• Locus tag: FVA72_RS19725
• Protein ID: WP_004905876.1
• Coordinates: 4269718..4270005 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVA72_RS19690	4265123..4265374	-	252	WP_110591062.1	DUF1471 domain-containing protein	-
FVA72_RS19695	4265645..4265983	+	339	WP_004905864.1	GIY-YIG nuclease family protein	-
FVA72_RS19700	4265956..4266459	-	504	WP_004905865.1	N-acetyltransferase	-
FVA72_RS19705	4266453..4266977	-	525	WP_004905868.1	SCP2 domain-containing protein	-
FVA72_RS19710	4267492..4268487	+	996	WP_094961644.1	U32 family peptidase	-
FVA72_RS19715	4268505..4269380	+	876	WP_096864325.1	U32 family peptidase	-
FVA72_RS19720	4269420..4269737	-	318	WP_110591061.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FVA72_RS19725	4269718..4270005	-	288	WP_004905876.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FVA72_RS19730	4270136..4271290	-	1155	WP_004905877.1	ABC transporter permease	-
FVA72_RS19735	4271290..4272435	-	1146	WP_004905879.1	ABC transporter permease	-
FVA72_RS19740	4272447..4273418	-	972	WP_110591060.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (14-104)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (10-75)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12206.90 Da
• Isoelectric Point: 8.4953

>T136283 WP_110591061.1 NZ_CP042861:c4269737-4269420 [Providencia sp. 1709051003]
MTQKPSNKRAKQPRQVAYTPTFKESWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFG

Nucleotide

• Length: 318 bp

>T136283 NZ_CP042861:c4269737-4269420 [Providencia sp. 1709051003]
TTGACTCAGAAGCCAAGTAATAAGCGAGCTAAGCAACCAAGGCAGGTTGCTTATACACCAACGTTTAAGGAGTCATGGGA
ACGATATAACCGAGCGGGCCGTAGGGATATGAATGCGGCTGTTCTCGTTATGGAAATACTGTTTTCTCAAAAAATAATAC
CAAAAGAATATCTTGACCATGAATTAGAAGGTCATGAATGGCAAGGAGCTAGGGAGCTTCATATTGGTGGTGATTTCTTA
CTGGTTTATCGCTTGTCAGATAAAGGTAATTTAATCACTTTCGTTGATATTGGTTCGCACAGTGAATTATTTGGTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10763.44 Da
• Isoelectric Point: 5.8809

>AT136283 WP_004905876.1 NZ_CP042861:c4270005-4269718 [Providencia sp. 1709051003]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Nucleotide

• Length: 288 bp

>AT136283 NZ_CP055325:c2230114-2229946 [Klebsiella michiganensis]
AACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGCGACAAAAGTG
GACGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A345M0A6