Detailed information of TA system TA136278

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1537891..1538548
• Replicon: chromosome
• Accession: NZ_CP042861
• Organism: Providencia sp. 1709051003

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FVA72_RS06845
• Protein ID: WP_110592138.1
• Coordinates: 1538138..1538548 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D4C097
• Locus tag: FVA72_RS06840
• Protein ID: WP_004261864.1
• Coordinates: 1537891..1538157 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVA72_RS06825	1534887..1535783	-	897	WP_165119666.1	hypothetical protein	-
FVA72_RS06830	1536028..1536648	-	621	WP_004261871.1	HD domain-containing protein	-
FVA72_RS06835	1536660..1537643	-	984	WP_110592139.1	tRNA-modifying protein YgfZ	-
FVA72_RS06840	1537891..1538157	+	267	WP_004261864.1	FAD assembly factor SdhE	Antitoxin
FVA72_RS06845	1538138..1538548	+	411	WP_110592138.1	protein YgfX	Toxin
FVA72_RS06850	1538648..1539166	-	519	WP_004261816.1	flavodoxin FldB	-
FVA72_RS06855	1539284..1540186	+	903	WP_004261814.1	site-specific tyrosine recombinase XerD	-
FVA72_RS06860	1540208..1540912	+	705	WP_096863312.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
FVA72_RS06865	1540922..1542655	+	1734	WP_110592137.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15602.55 Da
• Isoelectric Point: 10.7733

>T136278 WP_110592138.1 NZ_CP042861:1538138-1538548 [Providencia sp. 1709051003]
VVLWKSNLSISWKTQLFSTCVHGVIGMFLLLAPWSPGNSMIWLPLLVVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWRILKAPWFTRYGILLTLEALQGKPQKLHLWVAKDALSEENWRNLNQLLLQYPDI

Nucleotide

• Length: 411 bp

>T136278 NZ_CP042861:1538138-1538548 [Providencia sp. 1709051003]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACCCAACTGTTCTCAACCTGTGTTCATGGGGTCATTGGGAT
GTTTTTACTATTGGCTCCATGGTCCCCTGGTAACTCAATGATATGGTTGCCGCTATTAGTGGTTGTCGTTGCGAGTTGGG
CAAAGAGTCAGAAAAATATCAGTAAAATAAAAGGGGTTGCTGTACTGGTTAATGGTAATAAGGTTCAGTGGAAGAAAAAT
GAATGGAGAATACTGAAAGCACCTTGGTTTACCCGCTATGGTATATTACTGACACTAGAAGCGTTACAAGGTAAACCACA
AAAGCTCCATTTGTGGGTTGCAAAAGACGCATTGTCGGAAGAGAATTGGCGTAATTTAAACCAATTATTGCTGCAATACC
CTGATATTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10684.24 Da
• Isoelectric Point: 4.8942

>AT136278 WP_004261864.1 NZ_CP042861:1537891-1538157 [Providencia sp. 1709051003]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDDLTTHDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMIKLIQEKN
KNRGPVEI

Nucleotide

• Length: 267 bp

>AT136278 NZ_CP042861:1537891-1538157 [Providencia sp. 1709051003]
ATGGATATTGAGAATAAAGCGCGAATTCATTGGGCATGCCGCCGTGGTATGCGTGAATTAGATATTTCAATCATGCCGTT
TTTTGAGTATGAATATGATGACCTAACAACTCACGATAAGCAGGTATTTGTCCGTTTATTAGAATGTGCGGACCCTGATT
TATTCAATTGGCTAATGAATCACGGTCGTCCAGATGATGACGAACTTTTTCGTATGATTAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Structures

Antitoxin

• AlphaFold DB: A0A345M2Q5