Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 892008..892654 Replicon chromosome
Accession NZ_CP042861
Organism Providencia sp. 1709051003

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag FVA72_RS03940 Protein ID WP_004905417.1
Coordinates 892008..892211 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D4C184
Locus tag FVA72_RS03945 Protein ID WP_004905413.1
Coordinates 892286..892654 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA72_RS03915 888084..888422 + 339 WP_004905421.1 P-II family nitrogen regulator -
FVA72_RS03920 888433..889719 + 1287 WP_004905420.1 ammonium transporter AmtB -
FVA72_RS03925 889858..890727 - 870 WP_036958583.1 acyl-CoA thioesterase II -
FVA72_RS03930 890966..891424 + 459 WP_004905418.1 YbaY family lipoprotein -
FVA72_RS03940 892008..892211 - 204 WP_004905417.1 hemolysin expression modulator Hha Toxin
FVA72_RS03945 892286..892654 - 369 WP_004905413.1 Hha toxicity modulator TomB Antitoxin
FVA72_RS03950 893178..894548 - 1371 WP_110592389.1 murein transglycosylase D -
FVA72_RS03955 894630..895385 - 756 WP_110592388.1 hydroxyacylglutathione hydrolase -
FVA72_RS03960 895426..896160 + 735 WP_110592387.1 methyltransferase domain-containing protein -
FVA72_RS03965 896157..896627 - 471 WP_004905405.1 ribonuclease HI -
FVA72_RS03970 896682..897443 + 762 WP_094962150.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T136277 WP_004905417.1 NZ_CP042861:c892211-892008 [Providencia sp. 1709051003]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T136277 NZ_CP042861:c892211-892008 [Providencia sp. 1709051003]
ATGACCAAATCTGATTATCTGATGCGTTTAAGAAAATGCACCACAATTGAAACACTTGAGCGTGTCATTGAAAAAAATAA
GTATGAATTATCTGATGATGAGCTAGAGCTATTCTATTCAGCAGCAGATCACCGCTTAGCTGAACTCACAATGAATAAGC
TTTATGATAAAATCCCAGCGTCTGTTTGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14085.04 Da        Isoelectric Point: 4.4915

>AT136277 WP_004905413.1 NZ_CP042861:c892654-892286 [Providencia sp. 1709051003]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNHSLVAVLDDDLKCLTSKT

Download         Length: 369 bp

>AT136277 NZ_CP042861:c892654-892286 [Providencia sp. 1709051003]
ATGGATGAATACTCACCCAAAAGACATGATATAGCAGAACTAAAATACTTATGTAATAGTCTCAATAGAGACGCTATTTT
AAGCTTACAAAAAACAAATACACACTGGATTAATGATTTAAGCTCCCCGCAAAGCGCAGCCTTGAATGAACTCATTGAAC
ATATCGCTGCATTTGTATGGCGGTTTAAAATCAAATACCCAAAAGAAAATCTTGTTATATCACTTATCGAAGAATACCTC
GATGAGACCTATGATTTATTCGGCAGCCCAGTTATCACACTTAGTGAAATTATAGACTGGGAAGCAATGAATCACAGCCT
TGTCGCTGTGCTGGATGATGACCTAAAGTGCCTAACCAGCAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q6D9

References