Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2503420..2504336 Replicon chromosome
Accession NZ_CP042860
Organism Providencia sp. 1701091

Toxin (Protein)


Gene name - Uniprot ID A0A6G6PK18
Locus tag FVA70_RS11155 Protein ID WP_004910825.1
Coordinates 2503878..2504336 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6G6PJY5
Locus tag FVA70_RS11150 Protein ID WP_004910826.1
Coordinates 2503420..2503881 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA70_RS11120 2498854..2499327 - 474 WP_109912202.1 NUDIX domain-containing protein -
FVA70_RS11125 2499620..2500261 - 642 WP_164528843.1 leucine efflux protein LeuE -
FVA70_RS11130 2500747..2501601 + 855 WP_164528844.1 AraC family transcriptional regulator -
FVA70_RS11135 2501660..2502361 + 702 WP_123381951.1 AzlC family ABC transporter permease -
FVA70_RS11140 2502358..2502672 + 315 WP_004910828.1 AzlD domain-containing protein -
FVA70_RS11145 2502864..2503331 + 468 WP_109912201.1 DUF1456 family protein -
FVA70_RS11150 2503420..2503881 + 462 WP_004910826.1 DUF2384 domain-containing protein Antitoxin
FVA70_RS11155 2503878..2504336 + 459 WP_004910825.1 RES domain-containing protein Toxin
FVA70_RS11160 2504337..2505227 - 891 WP_117161936.1 LysR family transcriptional regulator -
FVA70_RS11165 2505273..2506231 - 959 Protein_2184 acetyl-CoA carboxylase carboxyl transferase subunit alpha -
FVA70_RS11170 2506337..2506759 - 423 WP_004910820.1 helix-turn-helix domain-containing protein -
FVA70_RS11175 2506790..2507353 - 564 WP_080641505.1 GNAT family N-acetyltransferase -
FVA70_RS11180 2507334..2508800 - 1467 WP_109912197.1 AMP nucleosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2502358..2555107 52749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-146)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(99-150)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17188.77 Da        Isoelectric Point: 6.2048

>T136275 WP_004910825.1 NZ_CP042860:2503878-2504336 [Providencia sp. 1701091]
MILYRLVKSSFIHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDLLLNQFSLLSIDINDRYVMKLSLD
HLPTDWQQDPAPTSTMDIGTTWLNNQDSLVLLIPSCIIPYEYNAIINPLHPQFQKAIHTVKPLDFSVDPRLA

Download         Length: 459 bp

>T136275 NZ_CP042860:2503878-2504336 [Providencia sp. 1701091]
ATGATTTTGTATCGATTGGTTAAATCCAGTTTTATTCACGATGCATGGTCTGGTCAAGGAGCCATGCTCTACGGTGGGCG
TTGGAATCATAAAGGAACTCCCGCTGTTTATACTTCAACCAGTATTTCATTAGCCACCCTTGAAATACTCGTTCACATCA
ATCAAGACTTACTATTAAACCAGTTCAGTTTGCTATCCATCGATATCAATGACAGGTACGTGATGAAATTATCGTTAGAC
CACCTTCCAACAGATTGGCAGCAAGACCCAGCGCCAACTTCTACCATGGATATTGGTACTACATGGCTAAATAACCAAGA
TAGCTTAGTATTATTAATTCCCTCTTGTATTATTCCCTACGAATACAATGCAATTATTAACCCGTTGCACCCGCAATTTC
AAAAAGCCATACATACCGTTAAACCGCTGGATTTTAGTGTTGACCCACGCTTAGCATAG

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 17060.54 Da        Isoelectric Point: 9.9140

>AT136275 WP_004910826.1 NZ_CP042860:2503420-2503881 [Providencia sp. 1701091]
MRNYIPTTPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAAGDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Download         Length: 462 bp

>AT136275 NZ_CP042860:2503420-2503881 [Providencia sp. 1701091]
ATGAGAAACTATATCCCCACAACCCCACTTCAACCGACTGCTTCATCTTTTAAACCACTATGGCGCCATGTAGGGTTACC
TGCCGAACGTGGTATTGAATTGACCCACTTCTTACGCCAAGGGCTGTCTGTCTCTGTTTTAGACAATATCCAAGAATGGT
CAGGGATGAGTAAAACTGAATTATTACGGATATCCGGCATTAATGAACGCAATATTGCTCGTCGCAAAAATGCAGGCCAA
CCCCTCAATGCTGATGAAAGCGAACGAATTGCTCGTCTAGTACGCGTATTCGATGCGGCAGTGCGTTTATTTAATGGAGA
TAAACATGCAGCAGGTGATTGGCTTAATCACCCCGTTAAAGGGTTAGGCCATTTACGCCCTATTGAGCTTATTGCGACAG
AAAGTGGAGCCATTGAGGTAATTGATTTGATTGGCCGCATTGAGCATGGTGTGTTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6PK18

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6PJY5

References