Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1511759..1512416 Replicon chromosome
Accession NZ_CP042860
Organism Providencia sp. 1701091

Toxin (Protein)


Gene name cptA Uniprot ID A0A6G6PHM2
Locus tag FVA70_RS06600 Protein ID WP_042851636.1
Coordinates 1512006..1512416 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G6PHM9
Locus tag FVA70_RS06595 Protein ID WP_004913039.1
Coordinates 1511759..1512025 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA70_RS06580 1508755..1509651 - 897 WP_164528562.1 hypothetical protein -
FVA70_RS06585 1509896..1510516 - 621 WP_164528563.1 HD domain-containing protein -
FVA70_RS06590 1510528..1511511 - 984 WP_164528564.1 tRNA-modifying protein YgfZ -
FVA70_RS06595 1511759..1512025 + 267 WP_004913039.1 FAD assembly factor SdhE Antitoxin
FVA70_RS06600 1512006..1512416 + 411 WP_042851636.1 protein YgfX Toxin
FVA70_RS06605 1512506..1513024 - 519 WP_164528565.1 flavodoxin FldB -
FVA70_RS06610 1513142..1514044 + 903 WP_164528566.1 site-specific tyrosine recombinase XerD -
FVA70_RS06615 1514066..1514770 + 705 WP_164528567.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FVA70_RS06620 1514780..1516513 + 1734 WP_164528568.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15612.59 Da        Isoelectric Point: 10.7733

>T136274 WP_042851636.1 NZ_CP042860:1512006-1512416 [Providencia sp. 1701091]
VVLWKSNLSISWKTQLFSTCVHGVIGMFLLLTPWSPGNSMIWLPLLVVVVASWAKSQKNISKIKGVAVLVNGNKLQWKKN
EWRILKAPWLTRYGILLTLEALQGKPQKIHLWVAKDALSEENWRNLNQLLLQYPDI

Download         Length: 411 bp

>T136274 NZ_CP042860:1512006-1512416 [Providencia sp. 1701091]
GTGGTCCTGTGGAAATCTAATCTCTCCATTTCATGGAAAACTCAATTGTTCTCAACCTGTGTTCATGGGGTCATTGGGAT
GTTTTTGCTTCTGACTCCATGGTCTCCTGGTAACTCAATGATATGGCTGCCGCTACTAGTGGTTGTCGTTGCGAGTTGGG
CAAAGAGTCAGAAAAATATCAGTAAAATAAAAGGGGTTGCTGTACTGGTTAATGGCAATAAGCTTCAGTGGAAGAAAAAC
GAGTGGCGAATACTGAAAGCACCTTGGCTTACTCGTTACGGCATATTGCTGACATTAGAAGCGTTACAAGGCAAACCGCA
AAAGATCCATTTATGGGTAGCTAAAGACGCACTTTCGGAGGAAAATTGGCGTAATTTAAACCAGTTATTGCTGCAATACC
CTGATATCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10674.24 Da        Isoelectric Point: 4.8780

>AT136274 WP_004913039.1 NZ_CP042860:1511759-1512025 [Providencia sp. 1701091]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDNLTTQDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMIKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT136274 NZ_CP042860:1511759-1512025 [Providencia sp. 1701091]
ATGGATATTGAGAATAAAGCGCGAATTCATTGGGCATGCCGCCGTGGTATGCGTGAATTAGATATTTCAATCATGCCGTT
TTTTGAGTATGAATATGATAACCTGACAACCCAAGATAAGCAGGTATTTGTTCGATTATTAGAATGTGCGGACCCTGACT
TATTCAACTGGTTAATGAATCATGGCCGCCCAGATGATGACGAACTTTTTCGTATGATTAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6PHM2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6PHM9

References