Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 879052..879697 Replicon chromosome
Accession NZ_CP042860
Organism Providencia sp. 1701091

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag FVA70_RS03815 Protein ID WP_004905417.1
Coordinates 879052..879255 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6G6PGA8
Locus tag FVA70_RS03820 Protein ID WP_004914480.1
Coordinates 879329..879697 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA70_RS03790 875155..875493 + 339 WP_004905421.1 P-II family nitrogen regulator -
FVA70_RS03795 875504..876784 + 1281 WP_109911900.1 ammonium transporter AmtB -
FVA70_RS03800 876923..877792 - 870 WP_109911901.1 acyl-CoA thioesterase II -
FVA70_RS03805 878032..878490 + 459 WP_004914482.1 YbaY family lipoprotein -
FVA70_RS03815 879052..879255 - 204 WP_004905417.1 hemolysin expression modulator Hha Toxin
FVA70_RS03820 879329..879697 - 369 WP_004914480.1 Hha toxicity modulator TomB Antitoxin
FVA70_RS03825 880220..881590 - 1371 WP_164528437.1 murein transglycosylase D -
FVA70_RS03830 881672..882427 - 756 WP_117162848.1 hydroxyacylglutathione hydrolase -
FVA70_RS03835 882468..883202 + 735 WP_004914475.1 methyltransferase domain-containing protein -
FVA70_RS03840 883199..883669 - 471 WP_004914473.1 ribonuclease HI -
FVA70_RS03845 883724..884485 + 762 WP_004914471.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T136273 WP_004905417.1 NZ_CP042860:c879255-879052 [Providencia sp. 1701091]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T136273 NZ_CP055305:c1425773-1425453 [Mannheimia pernigra]
ATGAGCGAGTATGTTCCCGATGTCGGCGATATTATTTGGCTGAATTTCACGCCACAGGCAGGGCATCGTCCAGTGGTGGT
TCTCACCCCAGCAAGCTATAACCAACTCACTAGCTTGCTCATCTGTTGCCCGCTAACCACCAAAATCAAGGGCTATCCGT
TTGAAGTGCATATTGCCGGCAAACCACAAAATGTGGTGCTTTCCGACCAAGTGAAAAGCCTTGATTGGCGAGTTCGTCAA
GCCGAATTTAAAGGGAAGATTGCAGAGAGTGAATTGGTGGAAATTCGGAAGAAGGTTGGGGTGTTGTTGGGGTTAGTATG
A

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14106.06 Da        Isoelectric Point: 4.3849

>AT136273 WP_004914480.1 NZ_CP042860:c879697-879329 [Providencia sp. 1701091]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNQSLVTVLDDDLKCLTSKT

Download         Length: 369 bp

>AT136273 NZ_CP042860:c879697-879329 [Providencia sp. 1701091]
ATGGATGAATACTCACCCAAAAGACACGATATAGCAGAACTAAAATACTTATGTAATAGCCTCAATAGAGACGCTATTTT
AAGCTTACAAAAAACAAATACACACTGGATTAATGATTTAAGCTCCCCGCAAAGCGCAGCCTTGAATGAACTTATTGAAC
ATATCGCTGCATTTGTATGGCGGTTTAAAATCAAATATCCAAAAGAAAATCTTGTTATATCACTTATCGAAGAGTATCTC
GATGAGACCTACGATTTATTCGGCAGCCCAGTCATCACGCTCAGTGAAATTATAGACTGGGAAGCAATGAATCAGAGTCT
TGTCACTGTGTTGGATGATGACCTAAAGTGTCTAACCAGCAAAACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6PGA8

References