Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5228296..5228812 Replicon chromosome
Accession NZ_CP042858
Organism Klebsiella pneumoniae strain QD23

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag FU841_RS26710 Protein ID WP_004178374.1
Coordinates 5228296..5228580 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FU841_RS26715 Protein ID WP_002886901.1
Coordinates 5228570..5228812 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU841_RS26685 5223691..5223999 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
FU841_RS26690 5224084..5224257 + 174 WP_032412860.1 hypothetical protein -
FU841_RS26695 5224260..5225003 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FU841_RS26700 5225360..5227498 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
FU841_RS26705 5227828..5228292 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FU841_RS26710 5228296..5228580 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FU841_RS26715 5228570..5228812 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FU841_RS26720 5228890..5230800 - 1911 WP_004152270.1 BglG family transcription antiterminator -
FU841_RS26725 5230823..5231977 - 1155 WP_002886900.1 lactonase family protein -
FU841_RS26730 5232044..5232784 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T136266 WP_004178374.1 NZ_CP042858:c5228580-5228296 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T136266 NZ_CP042858:c5228580-5228296 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT136266 WP_002886901.1 NZ_CP042858:c5228812-5228570 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT136266 NZ_CP042858:c5228812-5228570 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References