Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 4756741..4757651 Replicon chromosome
Accession NZ_CP042858
Organism Klebsiella pneumoniae strain QD23

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag FU841_RS24115 Protein ID WP_004144067.1
Coordinates 4756741..4757211 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6A8PHD0
Locus tag FU841_RS24120 Protein ID WP_023287184.1
Coordinates 4757208..4757651 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU841_RS24095 4752967..4753935 - 969 WP_074423483.1 IS5 family transposase -
FU841_RS24100 4754240..4754500 + 261 WP_017901409.1 hypothetical protein -
FU841_RS24105 4754689..4755657 - 969 WP_072096747.1 IS5 family transposase -
FU841_RS24110 4755659..4756654 - 996 WP_077254794.1 IS5 family transposase -
FU841_RS24115 4756741..4757211 - 471 WP_004144067.1 RES family NAD+ phosphorylase Toxin
FU841_RS24120 4757208..4757651 - 444 WP_023287184.1 DUF2384 domain-containing protein Antitoxin
FU841_RS24125 4757752..4758900 - 1149 Protein_4645 translesion error-prone DNA polymerase V subunit UmuC -
FU841_RS24130 4758947..4760434 - 1488 Protein_4646 Mov34/MPN/PAD-1 family protein -
FU841_RS24135 4760489..4761457 - 969 WP_074424072.1 IS5 family transposase -
FU841_RS24140 4761486..4762235 - 750 Protein_4648 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element aadA2 / ere(A) / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / aac(3)-IVa / aph(4)-Ia / sul2 / floR / blaCTX-M-65 / fosA3 / aph(3')-Ia / tet(C) / aph(3'')-Ib / aph(6)-Id / aac(3)-IId / mph(A) / dfrA12 / blaTEM-1B / blaNDM-3 / aadA16 / dfrA27 - 4373245..4915543 542298
- inside IScluster/Tn - - 4752967..4764379 11412


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T136262 WP_004144067.1 NZ_CP042858:c4757211-4756741 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T136262 NZ_CP042858:c4757211-4756741 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16522.84 Da        Isoelectric Point: 10.3013

>AT136262 WP_023287184.1 NZ_CP042858:c4757651-4757208 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT136262 NZ_CP055302:c1264021-1263569 [Mannheimia pernigra]
ATGATTTTTACTGTCGGTCTTGAAATCCCAGAGGATACCGAAACCACTGCTTACGGAATGATTGTTCCTGCCCTTTGTGA
ACACAATTACGGCTGTTTTTCTGCTGCTGATGAAGTCGAAGAGCTGTTACCAATGGTAACGGAAGCAATCCAACTCAATC
TTGAAAGTATGGCAGAAGACGGTTTTGACCTTACTACCCTCAAAGATAAAGGTATTCCACATTACAAAAACGATCCTGAA
TATGCTCATTTCAAGGACTGGTTTTTGGTGGATGTCGATATTTCACCTTATCTTGGTTCCAAACAACGCATTAACATCAC
AATGCCTGAATTTTTACTCAACCGTATTGACCGCCGTGTCGCCGCAATGGGCAACTTCTACAAAGACCGCAGTCACTTCT
TAGCAACTGCCGCTCATCGTGAACTACACGCTCATTCCAATACAGAGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384IED8

Antitoxin

Source ID Structure
AlphaFold DB A0A6A8PHD0

References