Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3982921..3983540 Replicon chromosome
Accession NZ_CP042858
Organism Klebsiella pneumoniae strain QD23

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FU841_RS20225 Protein ID WP_002892050.1
Coordinates 3983322..3983540 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FU841_RS20220 Protein ID WP_002892066.1
Coordinates 3982921..3983295 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU841_RS20210 3978073..3979266 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FU841_RS20215 3979289..3982435 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
FU841_RS20220 3982921..3983295 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FU841_RS20225 3983322..3983540 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FU841_RS20230 3983703..3984269 + 567 WP_002892030.1 maltose O-acetyltransferase -
FU841_RS20235 3984241..3984381 - 141 WP_004147370.1 hypothetical protein -
FU841_RS20240 3984402..3984872 + 471 WP_002892026.1 YlaC family protein -
FU841_RS20245 3984847..3986298 - 1452 WP_064151794.1 PLP-dependent aminotransferase family protein -
FU841_RS20250 3986399..3987097 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
FU841_RS20255 3987094..3987234 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FU841_RS20260 3987234..3987497 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T136259 WP_002892050.1 NZ_CP042858:3983322-3983540 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T136259 NZ_CP042858:3983322-3983540 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT136259 WP_002892066.1 NZ_CP042858:3982921-3983295 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT136259 NZ_CP042858:3982921-3983295 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References