136246

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3726508..3727207 Replicon chromosome
Accession NZ_CP042857
Organism Proteus mirabilis strain 1701092

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag FU796_RS17325 Protein ID WP_004249093.1
Coordinates 3726508..3726894 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag FU796_RS17330 Protein ID WP_004246828.1
Coordinates 3726887..3727207 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU796_RS17310 3722521..3723102 - 582 WP_012368524.1 DNA-3-methyladenine glycosylase I -
FU796_RS17315 3723353..3724258 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
FU796_RS17320 3724268..3726340 + 2073 WP_017827114.1 glycine--tRNA ligase subunit beta -
FU796_RS17325 3726508..3726894 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FU796_RS17330 3726887..3727207 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
FU796_RS17335 3727258..3727692 - 435 WP_004246827.1 hypothetical protein -
FU796_RS17340 3727685..3728569 - 885 WP_004249091.1 endonuclease/exonuclease/phosphatase family protein -
FU796_RS17345 3728787..3730073 - 1287 WP_074561560.1 DUF3748 domain-containing protein -
FU796_RS17350 3730210..3730827 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
FU796_RS17355 3731129..3731752 + 624 WP_004246821.1 guanylate kinase -
FU796_RS17360 3731807..3732082 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T136246 WP_004249093.1 NZ_CP042857:3726508-3726894 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T136246 NZ_CP042857:3726508-3726894 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT136246 WP_004246828.1 NZ_CP042857:3726887-3727207 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT136246 NZ_CP055294:c4811245-4810979 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References