Detailed information of TA system TA136246

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3726508..3727207
• Replicon: chromosome
• Accession: NZ_CP042857
• Organism: Proteus mirabilis strain 1701092

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: FU796_RS17325
• Protein ID: WP_004249093.1
• Coordinates: 3726508..3726894 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: FU796_RS17330
• Protein ID: WP_004246828.1
• Coordinates: 3726887..3727207 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FU796_RS17310	3722521..3723102	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
FU796_RS17315	3723353..3724258	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
FU796_RS17320	3724268..3726340	+	2073	WP_017827114.1	glycine--tRNA ligase subunit beta	-
FU796_RS17325	3726508..3726894	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FU796_RS17330	3726887..3727207	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
FU796_RS17335	3727258..3727692	-	435	WP_004246827.1	hypothetical protein	-
FU796_RS17340	3727685..3728569	-	885	WP_004249091.1	endonuclease/exonuclease/phosphatase family protein	-
FU796_RS17345	3728787..3730073	-	1287	WP_074561560.1	DUF3748 domain-containing protein	-
FU796_RS17350	3730210..3730827	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
FU796_RS17355	3731129..3731752	+	624	WP_004246821.1	guanylate kinase	-
FU796_RS17360	3731807..3732082	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T136246 WP_004249093.1 NZ_CP042857:3726508-3726894 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T136246 NZ_CP042857:3726508-3726894 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATCGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT136246 WP_004246828.1 NZ_CP042857:3726887-3727207 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT136246 NZ_CP055294:c4811245-4810979 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97