136242

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 12613..13214 Replicon chromosome
Accession NZ_CP042857
Organism Proteus mirabilis strain 1701092

Toxin (Protein)


Gene name doc Uniprot ID A0A1Z1SQZ4
Locus tag FU796_RS00055 Protein ID WP_036895893.1
Coordinates 12613..12996 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag FU796_RS00060 Protein ID WP_004246496.1
Coordinates 12993..13214 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU796_RS00030 7911..8480 + 570 WP_004249768.1 methyltransferase -
FU796_RS00035 8536..10023 - 1488 WP_164527249.1 PLP-dependent aminotransferase family protein -
FU796_RS00040 10152..10610 + 459 WP_164527250.1 GNAT family N-acetyltransferase -
FU796_RS00045 10706..11443 - 738 WP_164527251.1 sel1 repeat family protein -
FU796_RS00050 11552..12451 + 900 WP_017628715.1 N-acetylmuramic acid 6-phosphate etherase -
FU796_RS00055 12613..12996 - 384 WP_036895893.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FU796_RS00060 12993..13214 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FU796_RS00065 13436..14299 - 864 WP_164527252.1 YicC family protein -
FU796_RS00070 14426..15142 + 717 WP_004249760.1 ribonuclease PH -
FU796_RS00075 15224..15868 + 645 WP_164527253.1 orotate phosphoribosyltransferase -
FU796_RS00080 16187..16792 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
FU796_RS00085 16912..17370 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14518.52 Da        Isoelectric Point: 8.4945

>T136242 WP_036895893.1 NZ_CP042857:c12996-12613 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGRIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNTLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T136242 NZ_CP042857:c12996-12613 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCGCATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACCGACAATACGCTGGAAAACTTAACAGTGGAAGCGGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT136242 WP_004246496.1 NZ_CP042857:c13214-12993 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT136242 NZ_CP042857:c13214-12993 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATCTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCAGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z1SQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References